Browsing by Author "201-0010590"

Now showing items 41-60 of 68

    • Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival 
      Martínez Alvarado, P.; Dagnino Subiabre, Alexies; Paris Pizarro, Irmgard; Metodiewa, D.; Welch, C. J.; Olea Azar, Claudio; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Segura Aguilar, Juan (ACADEMIC PRESS INC, 2001-05-25)
      The endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line RCSN-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 muM ...
    • Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an ... 
      Vieites, Marisol; Smircich, Pablo; Parajón Costa, Beatriz; Rodríguez Borges, Jorge; Galaz, Verónica; Olea Azar, Claudio; Otero, Lucía; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Gómez Barrio, Alicia; Garat, Beatriz; Gambino, Dinorah (SPRINGER, 2008-06)
      In the search for new therapeutic tools against Chagas disease (American trypanosomiasis) palladium and platinum complexes of the bioactive ligand pyridine-2- thiol N-oxide were exhaustively characterized and evaluated in ...
    • Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive ... 
      Demoro, Bruno; Rossi, Miriam; Caruso, Francesco; Liebowitz, Daniel; Olea Azar, Claudio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Guiset, Helena; Moreno, Virtudes; Pizzo, Chiara; Mahler, Graciela; Otero, Lucía; Gambino, Dinorah (Springer, 2013)
      In the search for new metal-based drugs against diseases produced by trypanosomatid parasites, four organoruthenium(II) compounds [Ru2(p-cymene)2(L)2] X2, where L are bioactive 5-nitrofuryl-containing thiosemicarbazones ...
    • PRELlMINARY VOLTAMMETRIC DATA FOR THE OXIDATION OF 4-METHYLAMINOPHENETHYLAMINE DERIVATIVES IN BUFFER AND ... 
      Rojas, Evelyn; Norambuena, Ester; Olea Azar, Claudio; Reyes Parada, Miguel; Cassels Niven, Bruce (Sociedad Chilena de Química, 1993-10-15)
      The electrochemistry 01 a series 01 monoamine oxidase-inhibitory 4-Nmethyl and N,N-dimethylaminophenethylamines was studied using cyclic voltammetry. Electron transler was irreversible both in aqueous buffer.(pH = 7.4) and ...
    • Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes 
      Díaz Elizondo, Jessica; Chiong Lay, Mario; Rojas Rivera, Diego; Olea Azar, Claudio; Kwon, H. Moo; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006-12-01)
      Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells ...
    • Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species 
      Rojas Rivera, Andrés; Díaz Elizondo, Jessica; Parra Ortíz, María Valentina; Salas, Daniela; Contreras Ferrat, Ariel Eduardo; Toro, Barbra; Chiong Lay, Mario; Olea Azar, Claudio; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2009-11-03)
      We investigated the role of Ca2+ in generating reactive oxygen species (ROS) induced by hyposmotic stress (Hypo) and its relationship to regulatory volume decrease (RVD) in cardiomyocytes. Hypo-induced increases in cytoplasmic ...
    • Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins 
      Matos, Maria João; Pérez Cruz, Fernanda; Vazquez Rodriguez, Saleta; Uriarte, Eugenio; Santana, Lourdes; Borges, Fernanda; Olea Azar, Claudio (Elsevier, 2013)
      In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical ...
    • Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity ... 
      Rodríguez Arce, Esteban; Machado, Ignacio; Rodríguez, Belén; Lapier, Michel; Zúñiga, María Carolina; Maya Arango, Juan; Olea Azar, Claudio; Otero, Lucía; Gambino, Dinorah (Elsevier Inc., 2017)
      © 2017 Elsevier Inc. American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects ...
    • Semiempirical SCF-MO calculations on the tautomeric equilibrium of histamine in gas phase and in aqueous solution 
      Olea Azar, Claudio; Parra Mouchet, Julia (Sociedad Chilena de Química, 1998)
      The potential energy surface of hstamine monocation is calculated by MNDO types methodologies and by the Reaction Field model at CNDO/2 level, in order to rationalize the experimental findings about the relative abundance ...
    • Spin Trapping: An Essential Tool for the Study of Diseases Caused by Oxidative Stress 
      Barriga González, Germán; Olea Azar, Claudio; Zúñiga López, María C.; Folch Cano, Christian; Aguilera Venegas, Benjamín; Porcal, Williams; González, Mercedes; Cerecetto, Hugo (Bentham Science Publ, 2015)
      Electron spin resonance (ESR), called also electron paramagnetic resonance (EPR) together with the spin trapping technique, has allowed us to study and understand how free radicals are involved in various pathologies. In ...
    • Studies of inclusion complexes of natural and modified cyclodextrin with (+)catechin by NMR and molecular modeling 
      Jullian Matthaei, Carolina; Miranda, Sebastián; Zapata Torres, Gerald Amilcar; Mendizábal Emaldía, Fernando; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2007-05)
      The aim of this paper is to describe the inclusion properties and the factors affecting the complexation selectivity and stabilization of catechin (CA) into beta-cyclodextrin (beta-CD) and two of its derivatives, namely ...
    • Study of Coumarin-Resveratrol Hybrids as Potent Antioxidant Compounds 
      Matos, María; Mura Mardones, Francisco; Vázquez Rodríguez, Saleta; Borges, Fernanda; Santana, Lourdes; Uriarte, Eugenio; Olea Azar, Claudio (MDPI AG, 2015)
      In the present work we synthesized a selected series of hydroxylated 3-phenylcoumarins 5–8, with the aim of evaluating in detail their antioxidant properties. From an in depth study of the antioxidant capacity data ...
    • Substituent effect on the rate of the hydroxyl and phenyl radical spin trapping with nitrones 
      Sueishi, Y.; Yoshioka, C.; Olea Azar, Claudio; Reinke, L. A.; Kotake, Y. (CHEMICAL SOC JAPAN, 2002-09)
      Hydroxyl and phenyl radical spin trapping rates by alpha-phenyl-N-t-butylnitrone (PBN, N-benzylidene-t-butylamine N-oxide) and its analogs were determined using a competitive trapping method. Hydroxyl radical was generated ...
    • Synthesis and Electrochemical and Biological Studies of Novel Coumarin−Chalcone Hybrid Compounds 
      Pérez Cruz, Fernanda; Vazquez Rodriguez, Saleta; João Matos, Maria; Herrera Morales, Alejandra; Villamena, Frederick A.; Das, Amlan; Gopalakrishnan, Bhavani; Olea Azar, Claudio; Santana, Lourdes; Uriarte, Eugenio (American Chemical Society, 2013)
      A series of novel hydroxy-coumarin−chalcone hybrid compounds 2a−i has been synthesized by employing a simple and efficient methodology. An electrochemical characterization using cyclic voltammetry and ESR spectroscopy ...
    • Theoretical EPR study of Nitroindazoles: 3-Alkoxy, 3-Hydroxy and 3-Oxo Derivatives 
      Rodríguez Becerra, Jorge; Olea Azar, Claudio; Zapata Torres, Gerald Amilcar; Mendizábal Emaldía, Fernando; Gonzáles, Mercedez; Cerecetto, Hugo (SOC BRASILEIRA QUIMICA, 2010-07-01)
      Um estudo de DFT em derivados 5-NI foi realizado em diferentes níveis de teoria, a fim procurar a melhor metodologia para calcular constantes de acoplamento hiperfinas (hfccs), distribuições da densidade da rotação e ...
    • Theoretical study in [C2H4-Tl](+) and [C2H2-Tl](+) complexes 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2007-01)
      We studied the attraction between [C2Hn] and Tl(I) in the hypothetical [C2Hn-Tl](+) complexes (n = 2,4) using ab initio methodology. We found that the changes around the equilibrium distance C-Tl and in the interaction ...
    • Theoretical study of [Hg3(o-C6F4)3]n {benzene} (n = 1, 2) complexes 
      Mendizábal Emaldía, Fernando; Burgos, Darwin; Olea Azar, Claudio (Elsevier B.V., 2008-09)
      The electronic structure and spectroscopic properties of [Hg3(o-C6F4)3]n {benzene} (n = 1, 2) were studied at the HF, MP2 and PBE levels. The interaction between [Hg3(o-C6F4)3] and benzene at the HF and MP2 levels was ...
    • Theoretical Study of Electronic Spectra of [Pt-3(mu-CO)(3)(CO)(3)](n)(-2) (n=3-5) Complexes 
      Mendizábal Emaldía, Fernando; Burgos, Darwin; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2009-03-05)
      The platinum-platinum attraction and the spectroscopic properties of [Pt-3(mu-CO)(3)(CO)(3)](n)(-2) (n = 3-5) were Studied at the PBE level. Theoretical calculations are in agreement with experimental geometries. The ...
    • Theoretical study of the d(10)-d(8) interaction between Au(I) and Au(III) on the cis/trans-[PH3Au(I)C(L)= ... 
      Mendizábal Emaldía, Fernando; Zapata Torres, Gerald Amilcar; Olea Azar, Claudio (ELSEVIER, 2003-11-28)
      We have carried out an ab initio study designed to shed some light on the aurophilic attractions between Au(I) and Au(III) in the [PH3Au(I)C(L)=C(L)Au(III)(R)(2)PH3] (where R = -H, -CH3; L = -H, -CH3) model. Calculations ...
    • Theoretical study of the electronic spectrum of binuclear gold(I) complexes 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2005-05-15)
      The electronic structure and the spectroscopic properties of [Au-2(CS3)(2)](-2), [Au-2(pym-2-S)(2)] (pym = pyrimidethiolate), [Au-2(dpm)(2)](+2) (dpm = bis(diphosphino)methane) were studied using density functional theory ...