Browsing by Subject "Association"

Now showing items 1-19 of 19

    • Association between HLA-DQB1 alleles and type 1 diabetes in a case-parents study conducted in Santiago, Chile 
      Santos, J. L.; Pérez Bravo, Francisco; Carrasco, E.; Calvillán, M.; Albala Brevis, Cecilia (2001)
      The human leukocyte antigen (HLA) system plays a crucial role in the autoimmune process leading to childhood diabetes. The purpose of this study was to evaluate the association between type 1 diabetes and the polymorphism ...
    • Biomarkers for dementia in Latin American countries: gaps and opportunities 
      Parra, Mario A.; Orellana, Paulina; León Rodríguez, Tomás Ignacio; Cabello G., Victoria; Henríquez, Fernando; Gómez, Rodrigo; Avalos, Constanza; Damian, Andrés; Slachevsky Chonchol, Andrea María; Ibañez, Augustín; Zetterberg, Henrik; Tijms, Betty M.; Yokoyama, Jennifer S.; Piña Escudero, Stefanie D.; Cochran, J. Nicholas; Matallana, Diana L.; Acosta, Daisy; Allegri, Ricardo; Arias Suárez, Bianca P.; Barra, Bernardo; Behrens Pellegrino, María Isabel Ofelia; Brucki, Sonia M.D.; Busatto, Geraldo; Caramelli, Paulo; Castro Suarez, Sheila; Contreras, Valeria; Custodio, Nilton; Dansilio, Sergio; Cruz Puebla, Myriam de la; Cruz de Souza, Leonardo; Diaz, Mónica M.; Duque, Lissette; Farías Gontupil, Gonzalo Andrés; Ferreira, Sergio T.; Magrath Guimet, Nahuel; Kmaid, Ana; Lira, David; Lopera, Francisco; Mar Meza, Beatriz; Miotto, Eliane C.; Nitrini, Ricardo; Núñez, Alberto; O’Neill, Santiago; Ochoa, John; Pintado Caipa, Maritza; França Resende, Elisa de Paula; Risacher, Shannon; Rojas, Luz Angela; Sabaj, Valentina; Schilling, Lucas; Sellek, Allis F.; Sosa, Ana; Takada, Leonel T.; Teixeira, Antonio L.; Unaucho Pilalumbo, Martha; Durán Aniotz, Claudia (Wiley, 2022)
      Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities ...
    • Dementia caregiving across Latin America and the Caribbean and brain health diplomacy 
      Ibáñez, Agustín; Pina Escudero, Stefanie Danielle; Possin, Katherine L.; Quiroz, Yakeel T.; Aguzzoli Peres, Fernando; Slachevsky Chonchol, Andrea María; Sosa, Ana Luisa; Brucki, Sonia M. D.; Miller, Bruce L (Elsevier, 2021)
      The prevalence of dementia in Latin America and the Caribbean is growing rapidly, increasing the burden placed on caregivers. Exacerbated by fragile health-care systems, unstable economies, and extensive inequalities, ...
    • Disability-free life expectancy and life expectancy in good self-rated health in Chile: Gender differences ... 
      Moreno, Ximena; Lera Marques, Lydia; Albala Brevis, Cecilia (Public Library Science, 2020)
      Background Chile has one of the highest life expectancies at 60 years in South America. This study was aimed to determine healthy life expectancies among Chilean older people, according to self-rated health and disability, ...
    • Effects of dietary polyunsaturated fatty acid sources on expression of lipid‑related genes in bovine milk ... 
      Vargas-Bello-Pérez, Einar; Cancino Padilla, Nathaly; Geldsetzer Mendoza, Carolina Luisa; Morales Silva, María Sol; Leskinen, Heidi; Garnsworthy, Philip C.; Loor, Juan J.,; Romero Ormazábal, Jaime (Nature, 2020)
      The objective of this study was to compare the effect of contrasting sources of dietary n-6 and n-3 PUFA on expression of genes related to lipid metabolism in dairy cows. During 63 days, fifteen lactating cows were assigned ...
    • Environmental determinants of COVID‑19 transmission across a wide climatic gradient in Chile 
      Correa Araneda, Francisco; Ulloa Yáñez, Alfredo Alejandro; Núñez, Daniela; Boyero, Luz; Tonin, Alan M.; Cornejo, Aydeé; Urbina, Mauricio A.; Díaz, María Elisa; Figueroa Muñoz, Guillermo; Esse, Carlos (Nature Research, Germany, 2021)
      Several studies have examined the transmission dynamics of the novel COVID-19 disease in different parts of the world. Some have reported relationships with various environmental variables, suggesting that spread of the ...
    • Gallstones, body mass index, C-reactive protein, and gallbladder cancer: Mendelian randomization analysis ... 
      Barahona Ponce, Carol Mariom; Scherer, Dominique; Brinster, Regina; Boekstegers, Félix; Marcelain Cubillos, Katherine Jenny; Gárate Calderón, Valentina Constanza; Müller, Bettina; Toro, Gonzalo de; Retamales, Javier; Barajas Barajas, Olga Beatriz; Ahumada Olea, Monica Beatriz; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo; Portiño Roa, Sergio Fabián; Bertrán, María Enriqueta; Gabler, Fernando; Spencer, Loreto; Olloquequi, Jordi; Fischer, Christine; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Weiderpass, Elisabete; Bonet, Catalina; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Hveem, Kristian; Eklund, Niina; Völker, Uwe; Waldenberger, Melanie; Fuentes Guajardo, Macarena; González-Jose, Rolando; Bedoya, Gabriel; Bortolini, María C.; Cenizales Quinteros, Samuel; Gallo, Carla; Ruiz Linares, Andrés; Rothhammer, Francisco; Bermejo, Justo Lorenzo (Wiley, 2021)
      BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC is relatively rare in Europe. Here, we investigate ...
    • Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion 
      Cleynen, Isabelle; Engchuan, Worrawat; Hestand, Matthew S.; Heung, Tracy; Holleman, Aarón M.; Johnston, H. Richard; Monfeuga, Thomas; McDonald McGinn, Donna M.; Gur, Raquel E.; Morrow, Bernice E.; Swillen, Ann; Vorstman, Jacob A. S.; Bearden, Carrie E.; Chow, Eva W. C.; van den Bree, Marianne; Emanuel, Beverly S.; Vermeesch, Joris R.; Warren, Stephen T.; Owen, Michael J.; Chopra, Pankaj; Cutler, David J.; Duncan, Richard; Kotlar, Alex V.; Mulle, Jennifer G.; Voss, Anna J.; Zwick, Michael E.; Diacou, Alexander; Golden, Aaron; Guo, Tingwei; Lin, Jhih Rong; Wang, Tao; Zhang, Zhengdong; Zhao, Yingjie; Marshall, Christian; Merico, Daniele; Jin, Andrea; Lilley, Brenna; Salmons, Harold I.; Oanh, Tran; Pardinas, Antonio; Walters, James T. R.; Demaerel, Wolfram; Boot, Erik; Butcher, Nancy J.; Costain, Gregory A.; Lowther, Chelsea; Evers, Rens; van Amelsvoort, Therese A. M. J.; van Duin, Esther; Vingerhoets, Claudia; Breckpot, Jeroen; Devriendt, Koen; Vergaelen, Elfi; Vogels, Annick; Crowley, T. Blaine; McGinn, Daniel E.; Moss, Edward M.; Sharkus, Robert J.; Unolt, Marta; Zackai, Elaine H.; Calkins, Mónica E.; Gallagher, Robert S.; Gur, Rubén C.; Tang, Sunny X.; Fritsch Montero, Rosemarie; Ornstein Letelier, Claudia; Repetto, Gabriela M.; Breetvelt, Elemi; Duijff, Sasja N.; Fiksinski, Ania; Moss, Hayley; Niarchou, Maria; Murphy, Kieran C.; Prasad, Sarah E.; Daly, Eileen M.; Gudbrandsen, María; Murphy, Clodagh M.; Murphy, Declan G.; Buzzanca, Antonio; Di Fabio, Fabio; Digilio, María C.; Pontillo, María; Marino, Bruno; Vicari, Stefano; Coleman, Karlene; Cubells, Joseph F.; Ousley, Opal Y.; Carmel, Miri; Gothelf, Doron; Mekori Domachevsky, Ehud; Michaelovsky, Elena; Weinberger, Ronnie; Eliez, Stephan; Sandini, Corrado; Schneider, Maude; Bena, Frederique Sloan; Antshel, Kevin M.; Fremont, Wanda; Kates, Wendy R.; Belzeaux, Raoul; Busa, Tiffany; Schoch, Kelly; Shashi, Vandana; Simon, Tony J.; Tassone, Flora; Arango, Celso; Suner, Damia H.; Raventos Simic, Jasna; Epstein, Michael P.; Williams, Nigel M.; Bassett, Anne S. (Nature, 2020)
      Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that ...
    • Genetic polymorphisms as non-modifiable susceptibility factors to laryngeal cancer 
      Escalante, Paula; Barría, Tamara; Cancino Castañeda, Miguel; Rahal Espejo, Maritza; Cerpa, Leslie; Sandoval, Christopher; Molina Mellico, Sebastián; Suárez, Marcelo I.; Martínez, Matías; Cáceres Lillo, Dante; Quiñones, Luis Abel; Varela Figueroa, Nelson (Portland Press, 2020)
      Laryngeal squamous cell carcinoma (LSCC) is a highly disabling disease to the patient, affecting speech, swallowing and respiratory skills. Smoking and alcohol abuse are principal risk factors linked to this disease. Genetic ...
    • Genome wide association analysis for resistance to Caligus rogercresseyi in Atlantic salmon (Salmo salar L.) 
      Correa, K.; Lhorente, Jean Paul; López, M. E.; Figuera, R.; Bassini, Liane; Di Genova, Alex; Maass Sepúlveda, Alejandro; Davidson, W.; Yáñez López, José (Elsevier, 2017)
    • Linkage disequilibrium between MSX1 and non-syndromic cleft lip/palate in the Chilean population 
      Suazo, J.; Santos, J. L.; Carreño, H.; Jara, L.; Blanco, R. (SAGE Publications Inc., 2004)
      Non-syndromic cleft lip/palate (NSCLP) is a complex genetic trait. Linkage and association studies have suggested that a clefting locus could be located on chromosome 4p. Sixty Chilean families were recruited for this ...
    • Parent-of-origin effects for MSX1 in a Chilean population with nonsyndromic cleft lip/palate 
      Suazo, José; Santos, José Luis; Jara, Lilian; Blanco, Rafael (2010)
      Based on association and sequencing studies, investigators have postulated muscle segment homeobox 1 (MSX1) as a strong candidate gene involved in the causation of nonsyndromic cleft lip with or without cleft palate (NSCLP). ...
    • Predicting change in diagnosis from major depression to bipolar disorder after antidepressant initiation 
      Pradier, Melanie F.; Hughes, Michael C.; McCoy, Thomas H.; Barroilhet Díez, Agustín; Doshi Velez, Finale; Perlis, Roy H. (Springer Nature, 2020)
      We aimed to develop and validate classification models able to identify individuals at high risk for transition from a diagnosis of depressive disorder to one of bipolar disorder. This retrospective health records cohort ...
    • Relationship between age at giving fortified powdered cow's milk and cessation of breastfeeding on the ... 
      Retamal Yermani, Rodrigo; Mascie-Taylor, C. G. Nicholas; Villegas, Rodrigo; Rodríguez Osiac, Lorena (Nature, 2020)
      Background/objectives To examine how much of the variation in weight-for-height (WHZ)z-scores were associated with age at which breastfeeding ceased and provision of fortified cow's milk (Leche Purita Fortificada, LPF) ...
    • Resolving early obesity leads to a cardiometabolic profile within normal ranges at 23 years old in a ... 
      Correa Burrows, María Paulina; Rogan Castillo, Jose Antonio; Blanco, Estela; East, Patricia; Lozoff, Betsy; Gahagan, Sheila; Burrows Argote, Raquel del Carmen (Nature Research, 2021)
      Obesity is the most important predisposing factor for cardiovascular disease and type-2 diabetes. We explored the relationship between the age at onset of obesity and selected cardiometabolic parameters in young adults. ...
    • Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps 
      Adeyemo, Adebowale; Balaconis, Mary K.; Darnes, Deanna R.; Fatumo, Segun; Granados Moreno, Palmira; Hodonsky, Chani J.; Inouye, Michael; Kanai, Masahiro; Kato, Kazuto; Knoppers, Bartha M.; Lewis, Anna C. F.; Martin, Alicia R.; McCarthy, Mark I.; Meyer, Michelle N.; Okada, Yukinori; Richards, J. Brent; Richter, Lucas; Ripatti, Samuli; Rotimi, Charles N.; Sanderson, Saskia C.; Sturm, Amy C.; Verdugo Salgado, Ricardo Alejandro; Widen, Elisabeth; Willer, Cristen J.; Wojcik, Genevieve L.; Zhou, Alicia (Nature Research, 2021)
      Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human genome to estimate the risk of a disease or disease-related trait for an individual. The potential benefits of PRSs include ...
    • The Multisite PeachRefPop Collection: A True Cultural Heritage and International Scientific Tool for Fruit Trees 
      Cirilli, Marco; Micali, Sabrina; Aranzana, María José; Arús, Pere; Babini, Annarosa; Barreneche, Teresa; Bink, Marco; Cantin, Celia M.; Ciacciulli, Angelo; Cos-Terrer, José Enrique; Drogoudi, Pavlina; Eduardo, Iban; Foschi, Stefano; Giovannini, Daniela; Guerra, Walter; Liverani, Alessandro; Pacheco Cruz, Igor; Pascal, Thierry; Quilot-Turion, Benedicte; Verde, Ignazio; Rossini, Laura; Bassi, Daniele (Amer Soc Plant Biologists, 2020)
      Plants have evolved a range of adaptive mechanisms that adjust their development and physiology to variable external conditions, particularly in perennial species subjected to long-term interplay with the environment. ...
    • Validity assessment of the single-point insulin sensitivity estimator (spise) for diagnosis of cardiometabolic ... 
      Correa Burrows, Paulina; Blanco, Estela; Gahagan, Sheila; Burrows Argote, Raquel (Nature, 2020)
      Insulin measurements are not advised for cardiometabolic risk screening in large groups. Here we assessed the accuracy of the single-point insulin sensitivity estimator (SPISE) to diagnose cardiometabolic risk in Chilean ...
    • Whole genome re‑sequencing reveals recent signatures of selection in three strains of farmed Nile tilapia ... 
      Cádiz, María I.; López, María Eugenia; Díaz Domínguez, Diego; Cáceres Cruz, Giovanna; Yoshida, Grazyella Massako; Gómez Uchida, Daniel; Yáñez López, José (Nature, 2020)
      Nile tilapia belongs to the second most cultivated group of fish in the world, mainly because of its favorable characteristics for production. Genetic improvement programs and domestication process of Nile tilapia may have ...