Now showing items 1-20 of 91

    • ACE2 and vasoactive peptides: Novel players in cardiovascular/renal remodeling and hypertension 

      Mendoza Torres, Evelyn; Oyarzún, Alejandra; Mondaca Ruff, David; Azocar, Andrés; Chiong Lay, Mario; Castro, Pablo F.; Jalil Milad, Jorge; Lavandero González, Sergio; Ocaranza, María Paz (2015)
      The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and homeostasis due to its influence on the regulation of electrolyte balance, blood pressure, vascular tone and cardiovascular remodeling. ...
    • Activity of metalloproteinase-9 is related to oxidative stress in the acute coronary syndrome 

      Bittner, Alex; Castro Agüero, Pablo; Pérez, Osvaldo; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Andrés; Chiong Lay, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (OXFORD UNIV PRESS, 2006-08)
      Meeting Abstract
    • Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of sorbitol and mannitol 

      Gálvez, A. S.; Ulloa Valenzuela, Juan Alberto; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Eisner, Verónica; Barros, L.; Lavandero González, Sergio (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-03)
      Cells adapt to hyperosmotic conditions by several mechanisms, including accumulation of sorbitol via induction of the polyol pathway. Failure to adapt to osmotic stress can result in apoptotic cell death. In the present ...
    • Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes 

      Gutiérrez, Tomás; Parra, Valentina; Troncoso, Rodrigo; Pennanen, Christian; Contreras Ferrat, Ariel Eduardo; Vásquez Trincado, César Alonso; Morales, Pablo E.; López Crisosto, Camila; Sotomayor Flores, Cristian Alejandro; Chiong Lay, Mario; Rothermel, Beverly A.; Lavandero González, Sergio (BioMed Central Ltd., 2014)
      © 2014 Gutierrez et al.; licensee BioMed Central Ltd. Background: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes ...
    • Angiotensin II triggers apoptosis in cardiac fibroblast but not in myofibroblast overexpressing the type 1 receptor 

      Díaz Araya, Guillermo; Vivar Sánchez, Raúl; Soto, C.; Copaja, Miguel; Mateluna, F.; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; Thomas, W. G.; Lavandero González, Sergio (BLACKWELL PUBLISHING, 2007-07)
      Meeting Abstract
    • Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension 

      González, Leticia; Novoa, Ulises; Moya, Jackeline; Gabrielli, Luigi; Jalil Milad, Jorge; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Ocaranza, María Paz (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Hypertension-induced cardiovascular and renal damage can be mediated by activation of the renin-angiotensin-aldosterone system. There are different factors beyond renin-angiotensin-aldosterone system ...
    • Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro 

      Ocaranza, Maria Paz; Lavandero González, Sergio; Jalil Milad, Jorge; Moya, Jaqueline; Pinto, Melissa; Novoa, Ulises; Apablaza, Felipe; González, Leticia; Hernández, Carol; Varas, Manuel; López, René; Godoy, Iván; Verdejo, Hugo; Chiong Lay, Mario (Lippincott Williams and Wilkins, 2010)
      Background: Angiotensin-(1-9) is present in human and rat plasma and its circulating levels increased early after myocardial infarction or in animals treated with angiotensin-converting enzyme inhibitor. However, the ...
    • Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis 

      Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolás; García Nannig, Lorena; Novoa, Ulises; Ayala, Pedro; Díaz Araya, Guillermo; Godoy, Ivan; Chiong Lay, Mario; Lavandero González, Sergio; Jalil, J (Lippincott Williams and Wilkins, 2014)
      BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: ...
    • ANTIBODIES AGAINST FUNGAL CONIDIA AND ANTIBIOTICS INHIBIT PHENYLALANINE AMMONIA-LYASE ACTIVATION IN CITRUS 

      Quaas, Alex; Chiong Lay, Mario; Roco Arriagada, Ángela; Bravo, Roberto; Seelenfreund Hirsch, Daniela; Pérez Roepke, Luz María (GUSTAV FISCHER VERLAG, 1993-04)
      Antibodies raised against Trichoderma harzianum conidia prevented accumulation of Phenylalanine ammonia-lyase (PAL, E.C. 4.3.1.5.) in Citrus. The observed effect of the antibodies is produced by a delay in the formation ...
    • Apoptosis induced by hyperosmotic stress 

      Eisner, Verónica; Quiroga Lagos, Clara; Criollo Céspedes, Alfredo; Olea Azar, Claudio; Díaz Araya, Guillermo; Chiong Lay, Mario; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 2004)
      Meeting Abstract
    • Autofagia del cardiomiocito: ¿Un nuevo mecanismo de adaptación al estrés o de muerte celular? 

      Aránguiz Urroz, Pablo Daniel; Contreras Ferrat, Ariel Eduardo; Rojas Rivera, Diego; Troncoso Cotal, Rodrigo Hernán; Marambio Morales, Paola Angélica; Toro, Bárbara; Sanhueza Muñoz, Carlos Joaquín; Pennanen Saavedra, Christian; Díaz Elizondo, Jessica; Parra Ortíz, María Valentina; Chiong Lay, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      Históricamente, la apoptosis y la necrosis han sido consideradas como las dos formas fundamentales de muerte celular. Sin embargo, evidencias recientes sugieren que la muerte celular programada no está confinada sólo a ...
    • Autophagy in cardiovascular biology 

      Lavandero González, Sergio; Chiong Lay, Mario; Rothermel, Beverly A.; Hill, Joseph A. (American Society for Clinical Investigation, 2015)
      Cardiovascular disease is the leading cause of death worldwide. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing ...
    • Autophagy mediates tumor necrosis factor-alpha-induced phenotype switching in vascular smooth muscle A7r5 cell line 

      García Miguel, Marina; Riquelme, Jaime A.; Norambuena Soto, Ignacio; Morales, Pablo E.; Sanhueza Olivares, Fernanda; Núñez Soto, Constanza Belén; Mondaca Ruff, David; Cancino Arenas, Nicole; San Martín, Alejandra; Chiong Lay, Mario (Public library science, 2018-05-11)
      Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis ...
    • BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism 

      Rodríguez, Andrea E.; López Crisosto, Camila; Peña Oyarzún, Daniel; Salas, Daniela; Parra A., Valentina; Quiroga, Clara; Morawe, Tobías; Chiong Lay, Mario; Behl, Christian; Lavandero González, Sergio (Taylor and Francis, 2016)
      Autophagy is mainly regulated by post-translational and lipid modifications of ATG proteins. In some scenarios, the induction of autophagy is accompanied by increased levels of certain ATG mRNAs such as MAP1LC3B/LC3B, ATG5 ...
    • Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity 

      Pizarro, Marcela; Troncoso Cotal, Rodrigo; Martínez, Gonzalo J.; Chiong Lay, Mario; Castro, Pablo F.; Lavandero González, Sergio (Elsevier, 2016)
      Doxorubicin (Doxo) is one of the most effective anti-neoplastic agents but its cardiotoxicity has been an important clinical limitation. The major mechanism of Doxo-induced cardiotoxicity is associated to its oxidative ...
    • Biochemical characterization of proteins in the crab Homalaspis plana Caracterización bioquímica de las proteínas de jaiba mora (Homalaspis plana). 

      Abugoch James, Lilian; Guarda,; Chiong Lay, Mario (1995)
      Homalaspis plana is a crab found in the Pacific Ocean coasts from Guayaquil (Ecuador) all the way down to the Strait of Magellan, including all of the Chilean coast. This crustacean is an important resource because it ...
    • Carvedilol corrects interventricular and interventricular dyssynchrony in chronic heart failure. 

      Castro, Pablo; Mc-Nab, Pablo; Bittner, Alex; Greig, Douglas; Quintana, Juan Carlos; Chiong Lay, Mario; Díaz Araya, Guillermo; Valenzuela, Rodrigo; Vergara, I.; Corbalán, Ramón; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2005-02-01)
      Meeting Abstract
    • Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis 

      Parra Ortíz, María Valentina; Eisner, Verónica; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Moraga, Francisco; García, Alejandra; Haertel, Steffen; Jaimovich Pérez, Enrique; Zorzano, Antonio; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2008-01-15)
      Aims In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
    • Citrus limon seedlings without functional chloroplasts are unable to induce phenylalanine ammonia-lyase in response to inoculation with Alternaria alternata 

      Prieto, Humberto; Chiong Lay, Mario; Garrido, Jorge; Seelenfreund Hirsch, Daniela; Quaas, Alex; Pérez Roepke, Luz María (GUSTAV FISCHER VERLAG, 1997-05)
      A light-dependent bleaching of plastids was induced in lemon seedlings through cultivation in the presence of the herbicide Norfluorazon (NFZ). Also, etiolated seedlings were obtained by cultivation under continuous dark ...
    • Comparative subcellular distribution of apyrase from animal and plant sources. Characterization of microsomal apyrase 

      Valenzuela,; López,; Depix,; Mancilla,; Kettlun,; Catalán,; Chiong Lay, Mario; Garrido,; Traverso Cori, A. (1989)
      1. 1. Apyrase (ATP: diphosphohydrolase) has been found in the microsomal fraction of rat salivary gland, mammary gland and uterus. 2. 2. This enzyme, already described in plant tissues, is mainly present as a soluble ...