Browsing by Author "b5e6a148-6ab9-4188-8af6-b280eedaf972"

Now showing items 1-3 of 3

    • IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A 
      Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • IRE1 signaling exacerbates Alzheimer's disease pathogenesis 
      Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Alvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz Flores, Claudio (Springer, 2017)
      Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
    • Regulated Inositol Requiring Enzyme 1 dependent mRNA decay sets the threshold for dendritic cell survival 
      Tavernier, Simon J.; Osorio Olivares, Fabiola; Vandersarren, Lana; Vetters, Jessica; Vanlangenakke, Nele; Van Isterdael, Gert; Vergote, Karl; De Rycke, Riet; Parthoens, Eef; van de Laar, Lianne; Iwawaki, Takao; Valle, Juan R. del; Hu, Chih-Chi Andrew; Lambrecht, Bart N.; Janssens, Sophie (Nature Publishing Group, 2017)
      The IRE1/XBP1 signaling pathway is part of a cellular program that protects from endoplasmic reticulum (ER) stress, but also controls development and survival of immune cells. Loss of XBP1 in splenic type 1 conventional ...