Now showing items 1-16 of 16

    • Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging 

      Díaz García, Víctor; Guerrero, Simón; Díaz Valdivia, Natalia; Lobos González, Lorena; Kogan Bocian, Marcelo; Pérez Donoso, José; Quest, Andrew F. G. (NLM (Medline), 2018)
      Background: Numerous studies have proposed the use of fluorescent semiconductor nanoparticles or quantum dots (QDs) as novel tools to label cells and tumors. However, QD applications are limited by their toxicity in ...
    • Biomimetic, Mild Chemical Synthesis of CdTe-GSH Quantum Dots with Improved Biocompatibility 

      Pérez Donoso, José; Monrás, Juan P.; Bravo, Denisse; Aguirre, Adam; Quest, Andrew F. G.; Osorio Román, Igor; Aroca, Ricardo F.; Chasteen, Thomas G.; Vásquez, Claudio C. (2012)
      Multiple applications of nanotechnology, especially those involving highly fluorescent nanoparticles (NPs) or quantum dots (QDs) have stimulated the research to develop simple, rapid and environmentally friendly protocols ...
    • Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death 

      Parra, Valentina; Moraga, Francisco; Kuzmicic, Jovan; López Crisosto, Camila; Troncoso, Rodrigo; Torrealba, Natalia; Criollo Céspedes, Alfredo; Díaz Elizondo, Jessica; Rothermel, Beverly A.; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2013)
      Ceramides are important intermediates in the biosynthesis and degradation of sphingolipids that regulatenumerous cellular processes, including cell cycle progression, cell growth, differentiation and death. In ...
    • Calcium transport and signaling in mitochondria 

      Bravo Sagua, Roberto; Parra Ortíz, María Valentina; López Crisosto, Camila; Díaz, Paula; Quest, Andrew F. G.; Lavandero González, Sergio (Wiley, 2017-04)
      Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell survival and death decisions. Given their ...
    • Encapsulation of gold nanostructures and oil-in-water nanocarriers in microgels with biomedical potential 

      Inostroza Riquelme, Mariela; Vivanco, Andrea; Lara, Pablo; Guerrero Rivera, Simón; Salas Huenuleo, Edison; Chamorro, Alejandro; Leyton Campos, Lisette; Bolaños, Karen; Araya Fuentes, Eyleen; Quest, Andrew F. G.; Kogan Bocian, Marcelo; Oyarzún Ampuero, Felipe (MDPI, 2018-05)
      Here we report the incorporation of gold nanostructures (nanospheres or nanorods, functionalized with carboxylate-end PEG) and curcumin oil-in-water (O/W) nanoemulsions (CurNem) into alginate microgels using the dripping ...
    • Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics 

      Bravo Sagua, Roberto; Gutiérrez, Tomás; Paredes, Felipe; Gatica, Damián; Rodríguez, Andrea E.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Parra, Valentina; Quest, Andrew F. G.; Rothermel, Beverly A.; Lavandero González, Sergio (Elsevier, 2012)
      Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating damaged ...
    • Gastric cancer: Nanoparticles as tools to improve treatment efficacy 

      Guerrero, Ariel R.; Oyarzún Ampuero, Felipe; Hassan, Natalia; Corvalán, Alejandro; Quest, Andrew F. G.; Kogan Bocian, Marcelo (Bentham Science, 2016)
      In recent years, advances in nanotechnology have raised the specter of developing effective agents for the treatment of high-impact diseases, like gastric cancer, which remains one of the major causes of cancer deaths ...
    • Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma metastasis 

      Guerrero, Simón; Díaz García, Víctor; Contreras Orellana, Pamela; Muñoz Lara, Pablo; Palma, Sujey; Guzmán, Fanny; Lobos González, Lorena; Cárdenas, Areli; Rojas Silva, Ximena; Muñoz, Luis; Leyton Campos, Lisette; Kogan Bocian, Marcelo; Quest, Andrew F. G. (Future Medicine, 2018)
      AIM To track early events during lung metastasis, we labeled cells expressing (B16F10CAV1) or lacking CAV1 (B16F10mock) with gold nanoparticles conjugated to the peptide TAT (AuNPs-PEG-TAT). METHODS B16F10 expressing ...
    • Helicobacter pylori and epigenetic mechanisms underlying gastric carcinogenesis 

      Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (Baishideng Publishing Group Inc., 2015)
      The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, ...
    • Mechanisms of cell death: molecular insights and therapeutic perspectives 

      Díaz Cuevas, Laín; Chiong Lay, Mario; Quest, Andrew F. G.; Lavandero González, Sergio; Stutzin Schottlander, Andrés (NATURE PUBLISHING GROUP, 2005-11)
      Editorial Material
    • Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v beta 3 integrin that activates PKC alpha and RhoA 

      Ávalos, Ana María; Valdivia, A. D.; Muñoz, Nicolás; Herrera Molina, Rodrigo; Tapia Pineda, Julio; Lavandero González, Sergio; Chiong Lay, Mario; Burridge, Keith; Schneider, P.; Quest, Andrew F. G.; Leyton Campos, Lisette (COMPANY OF BIOLOGISTS LTD, 2009-10)
      Clustering of alpha v beta 3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A ...
    • Organelle communication: Signaling crossroads between homeostasis and disease 

      Bravo Sagua, Roberto; Torrealba Cárdenas, Natalia Belén; Paredes, Felipe; Morales, Pablo E.; Pennanen Saavedra, Christian; López Crisosto, Camila; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Chiong Lay, Mario; Hill, Joseph A.; Simmend, Thomas; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2014)
      Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are ...
    • Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer 

      Oyarzún Ampuero, Felipe; Guerrero Hernández, Ariel; Hassan López, Natalia; Morales Valenzuela, Javier; Bollo Dragnic, Soledad; Corvalán Rodríguez, Alejandro; Quest, Andrew F. G.; Kogan Bocian, Marcelo (Bentham, 2015)
      Organic and inorganic nanoparticles show great potential for cancer diagnosis and treatment. Because gastric cancer (GC) represents the second most deadly type of neoplasia worldwide, continued research efforts by scientists ...
    • Regulation of cardiomyocyte autophagy by calcium 

      Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...
    • Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024 

      Ferreccio, Catterina; Roa, Juan Carlos; Bambs, Claudia; Vives, Alejandra; Corvalán, Alejandro H.; Cortés, Sandra; Foerster, Claudia; Acevedo, Johanna; Huidobro, Andrea; Passi, Alvaro; Toro, Pablo; Covacevich, Yerko; Cruz, Rolando de la; Koshiol, Jill; Olivares, Mauricio; Miquel, Juan Francisco; Cruz, Francisco; Silva, Raúl; Quest, Andrew F. G.; Kogan Bocian, Marcelo; Castro, Pablo F.; Lavandero González, Sergio (BioMed Central, 2016)
      Background: Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molina's population ...
    • Therapeutic targeting of autophagy in myocardial infarction and heart failure 

      Riquelme, Jaime A.; Chávez, Myra N.; Mondaca Ruff, David; Bustamante, Mario; Vicencio, José M.; Quest, Andrew F. G.; Lavandero González, Sergio (Taylor & Francis, 2016)
      Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a ...