Browsing by Subject "Expression"

Now showing items 1-20 of 21

    • A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics 
      Sapoznik, Etai; Chang, Bo-Jui; Huh, Jaewon; Ju, Robert J.; Azarova, Evgenia; Pohlkamp, Theresa; Welf, Erik S.; Broadbent, David; Carisey, Alexandre F.; Stehbens, Samantha J.; Lee, Kyung-Min; Marín Valdés, Arnaldo; Hanker, Ariella B.; Schmidt, Jens C.; Arteaga, Carlos L.; Bin, Yang; Kobayashi, Yoshihiko; Tata, Purushothama Rao; Kruithoff, Rory; Doubrovinski, Konstantin; Shepherd, Douglas P.; Millett Sikking, Alfred; York, Andrew G.; Dean, Kevin M.; Fiolka, Reto P. (Elife, 2020)
      We present an oblique plane microscope (OPM) that uses a bespoke glass-tipped tertiary objective to improve the resolution, field of view, and usability over previous variants. Owing to its high numerical aperture optics, ...
    • Akkermansia muciniphila induces mitochondrial calcium overload and a -synuclein aggregation in an enteroendocrine ... 
      Amorim Neto, Dionisio Pedro; Pelegrini Bosque, Beatriz; Pereira de Godoy, Joao Vitor; Vieira Rodrigues, Paulla; Meneses, Darío Donoso; Tostes, Katiane; Costa Tonoli, Celisa Caldana; Carvalho, Hernandes Faustino de; González Billault, Christian; Castro Fonseca, Matheus de (Elsevier, 2022)
      The gut microbiota influence neurodevelopment, modulate behavior, and contribute to neurodegenerative disorders. Several studies have consistently reported a greater abundance of Akkermansia muciniphila in Parkinson disease ...
    • ALK-negative anaplastic large cell lymphoma: features and outcomes of 235 patients from the International ... 
      Shustov, Andrei; Cabrera Contreras, Maria Elena; Civallero, Mónica; Bellei, Mónica; Ko, Young Hyeh; Manni, Martina; Skrypets, Tetiana; Horwitz, Steven M.; De Souza, Carmino Antonio; Radford, John A.; Bobillo, Sabela; Prates, María Virginia; Ferreri, Andrés J. M.; Chiattone, Carlos; Spina, Michele; Vose, Julie M.; Chiappella, Annalisa; Laszlo, Daniele; Marino, Darío; Stelitano, Caterina; Federico, Massimo (Amer Soc Hematology, 2021)
      Anaplastic lymphoma kinase–negative anaplastic large cell lymphoma (ALK– ALCL) is an aggressive neoplasm of T-cell/null-cell lineage. The T-Cell Project is a global prospective cohort study that consecutively enrolled ...
    • Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model ... 
      Carrillo, Ileana; Nonato Rabelo, Rayane Aparecida; Barbosa, César; Rates, Mariana; Fuentes Retamal, Sebastián Andrés; González Herrera, Fabiola; Guzmán Rivera, Daniela Inés; Quintero, Helena; Kemmerling Weis, Ulrike; Castillo, Christian; Machado, Fabiana; Díaz Araya, Guillermo; Maya, Juan (Public Library Science, 2021)
      Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and is widely distributed worldwide because of migration. In 30% of cases, after years of infection and in the absence of treatment, ...
    • Autumn Royal and Ribier rape juice extracts reduced viability and metastatic potential of colon cancer cells 
      Valenzuela, Manuel A.; Bastías, Lorena; Montenegro, Ivan; Werner, Enrique; Madrid, Alejandro; Godoy, Patricio; Parraga, Mario; Villena, Joan (Hindawi Ltd, 2018)
      Antioxidants are known to be beneficial to health. This paper evaluates the potential chemopreventive and anticancer properties of phenolic compounds present in grape juice extracts (GJE) from Autumn Royal and Ribier ...
    • Crosstalk between tumor-infiltrating immune cells and cancer-associated Fibroblasts in tumor growth and ... 
      Soongsathitanon, Jarupa; Jamjuntra, Pranisa; Sumransub, Nuttavut; Yangngam, Supaporn; Fuente, Marjorie de la; Landskron Ramos, Glauben Tamara; Thuwajit, Peti; Hermoso, Marcela Alejandra; Thuwajit, Chanitra (Hindawi, 2021)
      Signals from the tumor microenvironment (TME) have a profound influence on the maintenance and progression of cancers. Chronic inflammation and the infiltration of immune cells in breast cancer (BC) have been strongly ...
    • Cytoplasmic CopZ-Like Protein and Periplasmic Rusticyanin and AcoP Proteins as Possible Copper Resistance ... 
      Navarro, Claudio A.; Bernath, Diego von; Martínez Bussenius, Cristóbal; Castillo Peñaloza, Rodrigo; Jerez Guevara, Carlos (American Society Microbiology, 2016)
      Acidophilic organisms, such as Acidithiobacillus ferrooxidans, possess high-level resistance to copper and other metals. A. ferrooxidans contains canonical copper resistance determinants present in other bacteria, such ...
    • Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast ... 
      Lobos González, Lorena; Bustos, Rocío; Campos, América; Silva, Valeria; Silva, Verónica; Jeldes, Emanuel; Salomón, Carlos; Varas Godoy, Manuel; Cáceres Verschae, Albano; Durán, Eduardo; Vera, Tamara; Ezquer, Fernando; Ezquer, Marcelo; Burzio, Verónica A.; Villegas, Jaime (Nature, 2020)
      During intercellular communication, cells release extracellular vesicles such as exosomes, which contain proteins, ncRNAs and mRNAs that can influence proliferation and/or trigger apoptosis in recipient cells, and have ...
    • Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of ... 
      Kane, Andrew D.; Niu, Youguo; Herrera Videla, Emilio; Morton, A. Jennifer; Giussani, Dino A. (Nature, 2016)
      Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decline, however ...
    • Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction ... 
      Sánchez Vergara, Gina; Chalmers, Stefanie; Ahumada, Xavier; Montecinos, Luis; Olmedo Alegría, Ivonne Odette; Eisner, Verónica; Riveros, Ana; Kogan, Marcelo J.; Lavandero González, Sergio; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2020)
      The heart is critically dependent on mitochondrial respiration for energy supply. Ischemia decreases oxygen availability, with catastrophic consequences for cellular energy systems. After a few minutes of ischemia, the ...
    • Interspecies effectors of a transgenerational memory of bacterial infection in Caenorhabditis elegans 
      Legüe, Marcela; Caneo, Mauricio; Águila, Blanca; Pollak Williamson, Bernardo; Calixto, Andrea (CellPress, 2022)
      The inheritance of memory is an adaptive trait. Microbes challenge the immunity of organisms and trigger behavioral adaptations that can be inherited, but how bacteria produce inheritance of a trait is unknown. We use ...
    • Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21 
      Carreras Sureda, Amado; Rubio Moscardo, Fanny; Olvera, Alex; Argilaguet, Jordi; Kiefer, Kerstin; Mothe, Beatriz; Meyerhans, Andreas; Brander, Christian; Vicente, Rubén (Public Library Science, 2016)
      Single nucleotide polymorphisms (SNPs) located in the chromosome region 17q12-q21 are risk factors for asthma. Particularly, there are cis-regulatory haplotypes within this region that regulate differentially the expression ...
    • Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription ... 
      Jaque Fernández, Francisco Ignacio; Jorquera, Gonzalo; Troc Gajardo, Jennifer; Pietri Rouxel, France; Gentil, Christel; Buvinic Radic, Sonja Milena; Allard, Bruno; Jaimovich Pérez, Enrique Zacarias; Jacquemond, Vincent; Casas Atala, Mariana Victoria (Rockefeller Univ Press, 2021)
      One of the most important functions of skeletal muscle is to respond to nerve stimuli by contracting. This function ensures body movement but also participates in other important physiological roles, like regulation of ...
    • Partial microduplication in the histone acetyltransferase complex member KANSL1 is associated with congenital ... 
      León, Luis; Benavides, Felipe; Espinoza, Karena; Vial, Cecilia; Alvarez Zenteno, Patricia; Lay Son, Guillermo; Miranda, Macarena; Repetto, Gabriela (Nature, 2017)
      22q11.2 microdeletion syndrome (22q11.2DS) is the most common microdeletion disorder in humans, with an incidence of 1/4000 live births. It is caused by a heterozygous deletion of 1.5-3 Mb on chromosome region 22q11.2. ...
    • PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response 
      Gupta, Ananya; Mosaraf Hossain, Muhammad; Read, Danielle E.; Hetz Flores, Claudio; Samali, Afshin; Gupta, Sanjeev (Nature, 2015)
      The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted ...
    • Prostate cancer survivors with symptoms of radiation cystitis have elevated fibrotic and vascular proteins in urine 
      Zwaans, Bernadette M. M.; Nicolai, Heinz E.; Chancellor, Michael B.; Lamb, Laura E. (Public Library Science, 2020)
      Radiation for pelvic cancers can result in severe bladder damage and radiation cystitis (RC), which is characterized by chronic inflammation, fibrosis, and vascular damage. RC development is poorly understood because bladder ...
    • Role of constitutive nitric oxide synthases in the dynamic regulation of the autophagy response of keratinocytes ... 
      Bahamondes Lorca, Verónica; Wu, Shiyong (Royal Society of Chemistry, 2020)
      Ultraviolet B (UVB) radiation induces autophagy responses, which play a role in the regulation of the oncogenic processes of irradiated cells. However, the mechanism of autophagy responses post-UVB irradiation remains to ...
    • STAT3 inhibition with galiellalactone effectively targets the prostate cancer stem-like cell population 
      Canesin, Giacomo; Maggio, Valentina; Palominos, Macarena; Stiehm, Anna; Contreras, Héctor R; Castellón, Enrique A.; Morote, Juan; Paciucci, Rosanna; Maitland, Norman J.; Bjartell, Anders; Hellsten, Rebecka (Nature Research, 2020)
      Cancer stem cells (CSCs) are a small subpopulation of quiescent cells with the potential to differentiate into tumor cells. CSCs are involved in tumor initiation and progression and contribute to treatment failure through ...
    • Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47 
      Saini, Neeraj; Baena, Andrés; Ng, Tony W.; Venkataswamy, Manjunatha; Kennedy, Steven C.; Kunnath Velayudhan, Shajo; Carreño Marquez, Leandro; Xu, Jiayong; Chan, John; Larsen, Michelle; Jacobs, William; Porcelli, Steven A. (Nature Publishing Group, 2016)
      Suppression of major histocompatibility complex (MHC) class II antigen presentation is believed to be among the major mechanisms used by Mycobacterium tuberculosis to escape protective host immune responses. Through a ...
    • T cell exosome–derived miR-142-3p impairs glandular cell function in Sjögren’s syndrome 
      Cortes Troncoso, Juan; Jang, Shyh-Ing; Pérez, Paola; Hidalgo, Jorge; Ikeuchi, Tomoko; Greenwell-Wild, Teresa; Warner, Blake M.; Moutsopoulos, Niki M.; Alevizos, Ilias (The American Society for Clinical Investigation, 2020)
      Sjogren's syndrome (SS) is a systemic autoimmune disease that mainly affects exocrine salivary and lacrimal glands. Local inflammation in the glands is thought to trigger glandular dysfunction and symptoms of dryness. ...