Now showing items 1-6 of 6

    • ATP Induces IL-1 beta Secretion in Neisseria gonorrhoeae-Infected Human Macrophages by a Mechanism Not Related to the NLRP3/ASC/Caspase-1 Axis 

      García, Killen; Escobar, Gisselle; Mendoza, Pablo; Beltran, Caroll; Pérez Molina, Claudio; Arancibia, Sergio; Vernal Astudillo, Rolando; Rodas, Paula I.; Acuña Castillo, Claudio; Escobar Álvarez, Alejandro (Hindawi, 2016)
      Neisseria gonorrhoeae (Ngo) has developed multiple immune evasion mechanisms involving the innate and adaptive immune responses. Recent findings have reported that Ngo reduces the IL-1 beta secretion of infected human ...
    • Lipopolysaccharide inhibits the channel activity of the P2X7 receptor 

      Leiva Salcedo, Elías; Coddou, Claudio; Rodríguez, Felipe; Penna, Antonello; López, Ximena; Neira, Tanya; Fernández, Ricardo; Imarai, Mónica; Rios, Miguel; Escobar, Jorge; Montoya, Margarita; Huidobro Toro, Juan; Escobar, Alejandro; Acuña Castillo, Claudio (2011)
      The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) ...
    • Neisseria gonorrhoeae Induces a Tolerogenic Phenotype in Macrophages to Modulate Host Immunity 

      Escobar Álvarez, Alejandro; Candia, Enzo; Reyes Cerpa, Sebastián; Villegas Valdés, Bélgica; Neira, Tanya; López Nitsche, Mercedes; Maisey, Kevin; Tempio, Fabián; Ríos, Miguel; Acuña Castillo, Claudio; Imarai, Mónica (Hindawi, 2013)
      Neisseria gonorrhoeae is the etiological agent of gonorrhoea, which is a sexually transmitted disease widespread throughout the world. N. gonorrhoeae does not improve immune response in patients with reinfection, suggesting ...
    • Neisseria gonorrhoeae Modulates Immunity by Polarizing Human Macrophages to a M2 Profile 

      Ortiz, María Carolina; Lefimil Puente, Claudia; Rodas, Paula I.; Vernal Astudillo, Rolando; López, Mercedes; Acuña Castillo, Claudio; Imarai, Mónica; Escobar, Alejandro (Public Library Science, 2015)
      Current data suggest that Neisseria gonorrhoeae is able to suppress the protective immune response at different levels, such as B and T lymphocytes and antigen-presenting cells. The present report is focused on gonococcus ...
    • PGC-1α-dependent mitochondrial adaptation is necessary to sustain IL-2-induced activities in human NK cells 

      Miranda, Dante; Jara, Claudia; Ibañez, Jorge; Ahumada, Viviana; Acuña Castillo, Claudio; Martin, Adrian; Córdova, Alexandra; Montoya, Margarita (Hindawi Publishing Corporation, 2016)
      © 2016 Dante Miranda et al.Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in antitumor defense reactions. NK cell effector functions are critically dependent on cytokines ...
    • Tolerogenic Dendritic Cells Derived from Donors with Natural Rubber Latex Allergy Modulate Allergen-Specific T-Cell Responses and IgE Production 

      Escobar Álvarez, Alejandro; Aguirre, Adam; Guzmán Meléndez, María Antonieta; González González, Rodrigo; Catalán Martina, Diego; Acuña Castillo, Claudio; Larrondo Lillo, Milton; López Nitsche, Mercedes; Pesce Reyes, Bárbara; Rolland, Jennifer; O’Hehir, Robyn; Aguillón Gutiérrez, Juan Carlos (2014)
      Natural rubber latex (NRL; Hevea brasiliensis) allergy is an IgE-mediated reaction to latex proteins. When latex glove exposure is the main sensitizing agent, Hev b 5 is one of the major allergens. Dendritic cells (DC), ...