| Author | dc.contributor.author | Gómez Jeria, Juan | |
| Author | dc.contributor.author | Parra Mouchet, Julia | es_CL |
| Author | dc.contributor.author | Morales Lagos, Demian | es_CL |
| Admission date | dc.date.accessioned | 2011-11-10T20:45:52Z | |
| Available date | dc.date.available | 2011-11-10T20:45:52Z | |
| Publication date | dc.date.issued | 1991-03-07 | |
| Cita de ítem | dc.identifier.citation | THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE, Volume: 82, Issue: 1-2, Pages: 201-209, 1991 | es_CL |
| Identifier | dc.identifier.issn | 0166-1280 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119358 | |
| General note | dc.description | Artículo de publicación ISI | es_CL |
| Abstract | dc.description.abstract | In order to examine environmental effects, the interaction oí histamine (HA) with a model of
the H2 receptor was analyzed using the self-consistent reaction field theory at the CNDO/21evel,
in vacuo, and in the presence oí a polarlzable continuum medium. The main findings reported in
this work are: (a) a concerted proton movement is not possible in vacuo or in the presence oí a
polarlzable medium; (b) the most stable form in all the systems and environments analyzed is the
one in which there is a proton transference from the model site to HA; (c) it seems necessary to
consider other possibilities in the receptor modeling in order to sustain the HA receptor activation
hypothesis. | es_CL |
| Patrocinador | dc.description.sponsorship | This work has reeeived financial support from FONDECYT (Projeet 111188).
Also, some funds from Universidad Austral de Chile (Projeet DIC 8-8823)
and Universidad de Chile (Projeet Q-2442) are gratefully aeknowledged. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | ELSEVIER SCIENCE BV | es_CL |
| Keywords | dc.subject | PROTON-TRANSFER | es_CL |
| Título | dc.title | Electrostatic medium effects upon histamine H2 receptor activation | es_CL |
| Document type | dc.type | Artículo de revista | |
