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Transduction for Pheromones in the Main Olfactory Epithelium Is Mediated by the Ca2 -Activated Channel TRPM5

Authordc.contributor.authorLópez Santillo, Fabián Andrés 
Authordc.contributor.authorDelgado Arriagada, Ricardo es_CL
Authordc.contributor.authorLópez, Roberto es_CL
Authordc.contributor.authorBacigalupo Vicuña, Juan es_CL
Authordc.contributor.authorRestrepo, Diego es_CL
Cita de ítemdc.identifier.citationThe Journal of Neuroscience, February 26, 2014 • 34(9):3268 –3278en_US
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractGrowing evidence suggests that the main olfactory epithelium contains a subset of olfactory sensory neurons (OSNs) responding to pheromones. One candidate subpopulation expresses the calcium activated cation channel TRPM5 (transient receptor potential channel M5). Using GFP driven by the TRPM5 promoter in mice, we show that this subpopulation responds to putative pheromones, urine, and major histocompatibility complex peptides, but not to regular odors or a pheromone detected by other species. In addition, this subpopulation of TRPM5-GFP OSNs uses novel transduction. In regular OSNs, odorants elicit activation of the cyclic nucleotide-gated (CNG) channel, leading to Ca2 gating of Cl channels; in TRPM5-GFP OSNs, the Ca2 -activated Cl ANO2 (anoctamin 2) channel is not expressed, and pheromones elicit activation of the CNG channel leading to Ca2 gating of TRPM5. In conclusion, we show that OSNs expressing TRPM5 respond to pheromones, but not to regular odors through the opening of CNG channels leading to Ca2 gating of TRPM5.en_US
Patrocinadordc.description.sponsorshipMIDEPLAN Grant ICM-P05-001 (J.B.); and Fondo Nacional de Desarrollo Científico y Tecnolo´gico (FONDECYT) Grants 1100682 (J.B.), DC04657 (D.R.), DC006070 (D.R.), and TW007920 (J.B. and D.R.).en_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Títulodc.titleTransduction for Pheromones in the Main Olfactory Epithelium Is Mediated by the Ca2 -Activated Channel TRPM5en_US
Document typedc.typeArtículo de revistaen_US

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile