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Oxidation of C4-hydroxyphenyl 1,4-dihydropyridines in dimethylsulfoxide and its reactivity towards alkylperoxyl radicals in aqueous medium

Authordc.contributor.authorNúñez Vergara, Luis es_CL
Authordc.contributor.authorSalazar González, Ricardo Andrés es_CL
Authordc.contributor.authorCamargo Grandón, Rodrigo es_CL
Authordc.contributor.authorCarbajo, J. es_CL
Authordc.contributor.authorConde, B. es_CL
Authordc.contributor.authorNavarrete Encina, Patricio 
Authordc.contributor.authorSquella Serrano, Juan es_CL
Admission datedc.date.accessioned2008-09-01T16:11:04Z
Available datedc.date.available2008-09-01T16:11:04Z
Publication datedc.date.issued2007-06-15
Cita de ítemdc.identifier.citationBIOORGANIC & MEDICINAL CHEMISTRY 15(12):4318-4326en
Identifierdc.identifier.issn0968-0896
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120486
Abstractdc.description.abstractThis work reports the electrochemical oxidation of three newly synthesized C4-hydroxyphenyl-substituted 1,4-dihydropyridine derivatives in dimethylsulfoxide. The reactivity of the compounds with ABAP-derived alkylperoxyl radicals in aqueous buffer pH 7.4, was also studied. The oxidation mechanism involves the formation of the unstable dihydropyridyl radical, which was confirmed by controlled-potential electrolysis (CPE) and ESR experiments. The final product of the CPE, that is, pyridine derivative, was identified by GC-MS technique for the three derivatives. A direct reactivity of the synthesized compounds toward ABAP-derived alkylperoxyl radicals was found. The pyridine derivative was identified by GC-MS as the final product of the reaction. Results reveal that this type of 1,4-DHPs significantly reacts with the radicals, even compared with commercial 1,4-DHP drugs with a well-known antioxidant ability.en
Lenguagedc.language.isoenen
Publisherdc.publisherPERGAMON-ELSEVIER SCIENCEen
Keywordsdc.subjectVoltammetryen
Títulodc.titleOxidation of C4-hydroxyphenyl 1,4-dihydropyridines in dimethylsulfoxide and its reactivity towards alkylperoxyl radicals in aqueous mediumen
Document typedc.typeArtículo de revistaen


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