CHEMICAL BONDING OF METRONIDAZOLE SEMIESTERS WITH STARCH
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The incorporation of [1-(2-hydroxyethyl)-2-methyl-5-nitro-imidazole] (metronidazole), modified by treatment with succinic, glutaric and phtalic anhydrides on starch was studies. For the reaction the starch was previously activated with pyridine-water until gelification in the presence of dicyclohexylcarbodiimide (DCC) as a dehydrant agent and N,N,-dimethylaminopyridine (DAMP) as a catalyst. Incorporation of metronidazole on starch ranged up to 21.20%. Products were characterized by IR spectroscopy, and the incorporated drug determined by releasing the nitrate ion from the metronidazole followed by its quantification by a colorimetric technique.