Show simple item record

Authordc.contributor.authorPérez, Osvaldo 
Authordc.contributor.authorCastro Agüero, Pablo es_CL
Authordc.contributor.authorDíaz Araya, Guillermo es_CL
Authordc.contributor.authorNettle Nettle, Daniels Maurice es_CL
Authordc.contributor.authorMoraga, Francisco es_CL
Authordc.contributor.authorChiong Lay, Mario es_CL
Authordc.contributor.authorJalil Milad, Jorge es_CL
Authordc.contributor.authorZalaquett Sepúlveda, Ricardo es_CL
Authordc.contributor.authorMorán, Sergio es_CL
Authordc.contributor.authorBecker, Pedro es_CL
Authordc.contributor.authorCorbalán, Ramón es_CL
Authordc.contributor.authorLavandero González, Sergio es_CL
Admission datedc.date.accessioned2010-03-26T13:11:43Z
Available datedc.date.available2010-03-26T13:11:43Z
Publication datedc.date.issued2002-08
Cita de ítemdc.identifier.citationREVISTA ESPANOLA DE CARDIOLOGIA 55(8): 831-837en_US
Identifierdc.identifier.issn0300-8932
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120903
Abstractdc.description.abstractIntroduction and objective. Chronic heart failure (CHF) is associated with oxidative stress. Heart transplantation, an important therapeutic alternative in these patients, could reduce oxidative stress by improving cardiac function. Our aim was to evaluate post-heart transplantation oxidative stress. Patients and method. We studied three experimental groups: a) heart transplant recipients without evidence of rejection (n = 11); b) NYHA class III CHF patients (n = 19), and c) healthy control subjects (n = 14). Oxidative stress was assessed by measuring plasma malondialdehyde levels (MDA), and determining the enzymatic activities of glutathione peroxidase (GSH-Px), catalase (CAT), and superoxide dismutase (SOD). Results. The demographic characteristics of the three groups were similar. Mean time from transplantation was 20.0 +/- 4.8 months. Mean MDA plasma levels in heart transplantation and CHF patients were significantly higher than in normal subjects (3.35 +/- 0.8; 3.27 +/-1.7 y 0.9 +/- 0.3 muM, respectively). GSH-Px activity increased after transplantation compared to control subjects (0.40 +/- 0.06 and 0.33 +/- 0.05 U/g Hb, respectively), but not the CHF group. A significant decrease in SOD activity was found in the heart transplant vs. CHF group (0.44 +/- 0.1 vs. 0.87 +/- 0.6 U/mg Hb). There were no differences in CAT values between heart transplant and CHF patients. Conclusion. These findings demonstrated the presence of permanent oxidative stress in patients who have undergone heart transplantation, characterized by an increase in MDA and a decrease in SOD activity, despite an increase in GSH-Px activity.en_US
Lenguagedc.language.isoesen_US
Publisherdc.publisherEDICIONES DOYMA S/Len_US
Keywordsdc.subjectHeart failureen_US
Títulodc.titlePersistence of oxidative stress after heart transplantation: A comparative study of patients with heart transplant versus chronic stable heart failure. Persistencia del estrés oxidativo postrasplante cardíaco: estudio comparativo entre pacientes con trasplante cardíaco y con insuficiencia cardíaca crónica estable.en_US
Document typedc.typeArtículo de revistaen_US


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record