Organometallic Schiff bases derived from 5-nitrothiophene and 5-nitrofurane: Synthesis, crystallographic, electrochemical, ESR and antiTrypanosoma cruzi studies
Author
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Arancibia, Rodrigo
Author
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Klahn, A. Hugo
es_CL
Author
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Buono Core, Gonzalo E.
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Author
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Contreras, Daniel
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Author
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Barriga, Germán
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Author
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Olea Azar, Claudio
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Author
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Lapier, Michel
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Author
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Maya Arango, Juan
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Author
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Ibañez, Andrés
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Author
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Garland, María Teresa
es_CL
Admission date
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2014-01-10T13:48:13Z
Available date
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2014-01-10T13:48:13Z
Publication date
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2013
Cita de ítem
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Journal of Organometallic Chemistry 743 (2013) 49e54
en_US
Identifier
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DOI: 10.1016/j.jorganchem.2013.06.014
Identifier
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https://repositorio.uchile.cl/handle/2250/121738
General note
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Artículo de publicación de ISI
en_US
Abstract
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In the search for new therapeutic tools for the treatment of American trypanosomiasis, a series of novel
ferrocene and cyrhetrene imine compounds, derived from 5-nitro-heterocycles, were designed, synthesized
and characterized. The 1H and 13C NMR spectra indicated that these compounds adopted an
anti-(E) conformation in solution, and this was confirmed by X-ray crystallography for one of the
complexes (NT2). To study the relationship between the physicalechemical properties of N-iminyl
substituents of nitrofurfuryl and nitrothienyl groups and their antitrypanosomal activity, we have carried
out cyclic voltammetry and electron spin resonance studies of a series of organometallic imine
compounds. The results demonstrated that the electronic properties of the side chain of the
5-nitroheterocyclic compound could be correlated to its trypanocidal effect.