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Authordc.contributor.authorPessoa Mahana, Hernán 
Authordc.contributor.authorGonzález Lira, Christian es_CL
Authordc.contributor.authorFierro, Angélica es_CL
Authordc.contributor.authorZapata Torres, Gerald Amilcar es_CL
Authordc.contributor.authorPessoa Mahana, Carlos David es_CL
Authordc.contributor.authorOrtiz Severin, Javiera es_CL
Authordc.contributor.authorIturriaga-Vásquez, Patricio es_CL
Authordc.contributor.authorReyes Parada, Miguel es_CL
Authordc.contributor.authorSilva Matus, Paul es_CL
Authordc.contributor.authorSaitz Barría, Claudio es_CL
Authordc.contributor.authorAraya Maturana, Ramiro es_CL
Admission datedc.date.accessioned2014-01-13T12:56:49Z
Available datedc.date.available2014-01-13T12:56:49Z
Publication datedc.date.issued2013
Cita de ítemdc.identifier.citationBioorganic & Medicinal Chemistry 21 (2013) 7604–7611en_US
Identifierdc.identifier.otherDOI: 10.1016/j.bmc.2013.10.036
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/121748
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractA series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a–d and 5a– f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter (SERT) and the 5-HT1A receptor. Compounds 5b and 5f showed nanomolar affinities for both targets. The experimental data were rationalized according to results obtained from docking experiments. These findings are in agreement with our proposal that bis-indole derivatives can bind both targets, and might serve as leads in the quest of ligands endowed with a dual mechanism of action.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherElsevieren_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectPiperazinylpropylindole derivativesen_US
Títulodc.titleSynthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptoren_US
Document typedc.typeArtículo de revista


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile