Nonsteroidal Anti-Inflammatory Drug Determination in Water Samples by HPLC‑-DAD under Isocratic Conditions
Author
dc.contributor.author
Ascar Estay, María Loreto
Author
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Ahumada Torres, Aída Inés de Lourdes
es_CL
Author
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López, Alicia
es_CL
Author
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Quintanilla, Francia
es_CL
Author
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Leiva, Karla
es_CL
Admission date
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2014-03-06T19:34:18Z
Available date
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2014-03-06T19:34:18Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
J. Braz. Chem. Soc., Vol. 24, No. 7, 1160-1166, 2013
en_US
Identifier
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doi 10.5935/0103-5053.20130150
Identifier
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https://repositorio.uchile.cl/handle/2250/121841
General note
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Artículo de publicación ISI
en_US
Abstract
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Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of medications widely used by man to heal certain ailments. However, after consumption, they may be excreted in wastewaters with consequent environmental effects. NSAIDs are endocrine disruptors that can cause changes in animal physiology. The purpose of this study was to implement an analytical method that permits the determination of the presence of NSAIDs in water. Compound extraction was performed by solid‑-phase extraction (SPE) using an Oasis HLB cartridge. Analytes were analyzed by high‑-performance liquid chromatography with diode array detection (HPLC-DAD). The method was applied in water from the Maipo River and from a neighboring wastewater treatment plant in the Metropolitan Region of Pajaritos, Viña, Tuberia, Unión and Gansos sampling points in Chile. This method turned out to be adequate for the determination of NSAIDs in water samples with recovery percentages above 80%. Naproxen and ibuprofen were mostly detected in the Maipo River water samples, with concentrations ranging from 0.33 to 0.83 μg L-1.