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Weight Increase Is Associated with Skeletal Muscle Immunostaining for Advanced Glycation End Products, Receptor for Advanced Glycation End Products, and Oxidation Injury

Authordc.contributor.authorMaza Cave, María Pía de la es_CL
Authordc.contributor.authorUribarri, Jaime es_CL
Authordc.contributor.authorOlivares, Daniela es_CL
Authordc.contributor.authorHirsch Birn, Sandra es_CL
Authordc.contributor.authorLeiva Balich, Laura es_CL
Authordc.contributor.authorBarrera Acevedo, María Gladys 
Authordc.contributor.authorBunout Barnett, Daniel es_CL
Admission datedc.date.accessioned2010-01-27T20:37:16Z
Available datedc.date.available2010-01-27T20:37:16Z
Publication datedc.date.issued2008-12
Cita de ítemdc.identifier.citationREJUVENATION RESEARCH, Volume: 11, Issue: 6, Pages: 1041-1048, 2008en_US
Identifierdc.identifier.issn1549-1684
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/123950
Abstractdc.description.abstractBackground: Tissue accumulation of advanced glycation end products (AGEs) is associated with ageing, both in diabetics and nondiabetic subjects. Aim: The purpose of this study was to assess immunostaining for AGEs, specifically carboxymethyl-lysine (CML) and receptor for AGEs (RAGE), in muscle tissue of healthy male subjects differing in age and weight stability. Methodology: Muscle tissue was obtained during hernia surgery in middle-aged men reporting weight maintenance (WM, n 10) or weight gain (WG, n 7), and also in 4 elderly men. Tissue inmunostaining for CML and RAGE was performed. Results: Intensity of CML and RAGE staining were highly correlated (r 0.84) and also significantly associated with weight change and age. Muscle AGEs accretion was statistically associated with muscle expression of oxidative injury (8–hydroxy-deoxyguanosine and 4-hydroxy-2-nonenal) and inflammatory markers (tumor necrosis factor- ). Discussion: The increase of skeletal muscle AGEs/RAGE and markers of inflammation and oxidative injury in association with weight gain and old age suggest a pathogenic role of AGEs in weight gain and in sarcopenia of aging.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherMARY ANN LIEBERT INCen_US
Keywordsdc.subjectCALORIE RESTRICTIONen_US
Títulodc.titleWeight Increase Is Associated with Skeletal Muscle Immunostaining for Advanced Glycation End Products, Receptor for Advanced Glycation End Products, and Oxidation Injuryen_US
Document typedc.typeArtículo de revistaen_US


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