Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
MetadataShow full item record
The palladium(II) bis-chelate complexes of the type [Pd(TSC1−5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)- thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3-hydroxybenzaldehyde)- thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl- 1-(1-nitro-2-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (IC50 = 0.01–9.87 𝜇M) exhibited higher antiproliferative activity than their free ligands (IC50 = 23.48–70.86 and >250 𝜇M) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 𝜇M, resp.).
Artículo de publicación ISI
DOI: DOI: 10.1155/2013/524701