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Authordc.contributor.authorLatorre, Mauricio 
Authordc.contributor.authorLow, Marcela 
Authordc.contributor.authorGárate, Esteban 
Authordc.contributor.authorReyes Jara, Angélica 
Authordc.contributor.authorMurray, Bárbara E. 
Authordc.contributor.authorCambiazo Ayala, Verónica 
Authordc.contributor.authorGonzález, Mauricio 
Admission datedc.date.accessioned2015-10-27T19:36:46Z
Available datedc.date.available2015-10-27T19:36:46Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationMetallomics Vol. 7 No. 7 2015en_US
Identifierdc.identifier.otherDOI: 10.1039/c5mt00043b
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/134711
General notedc.descriptionArtículo de publicación ISIen_US
General notedc.descriptionSin acceso a texto completo
Abstractdc.description.abstractBy integrating the microarray expression data and a global E. faecalis transcriptional network we identified a sub-network activated by zinc and copper. Our analyses indicated that the transcriptional response of the bacterium to copper and zinc exposure involved the activation of two modules, module I that contains genes implicated in zinc homeostasis, including the Zur transcriptional repressor, and module II containing a set of genes associated with general stress response and basal metabolism. Bacterial exposure to zinc and copper led to the repression of the zinc uptake systems of module I. Upon deletion of Zur, exposure to different zinc and copper conditions induced complementary homeostatic mechanisms (ATPase efflux proteins) to control the intracellular concentrations of zinc. The transcriptional activation of zinc homeostasis genes by zinc and copper reveals a functional interplay between these two metals, in which exposure to copper also impacts on the zinc homeostasis. Finally, we present a new zinc homeostasis model in E. faecalis, positioning this bacterium as one of the most complete systems biology model in metals described to date.en_US
Patrocinadordc.description.sponsorshipFondo Nacional de Desarrollo Cientifico y Tecnologico, FONDECYT 1110427 11121449 1120254 Fondo Nacional de Desarrollo de Areas Prioritarias FONDAP-15090007 Center for Genome Regulation (CGR)en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherRoyal Soc Chemistryen_US
Keywordsdc.subjectBacillus-Subtilis Zuren_US
Keywordsdc.subjectCorynebacterium-Glutamicumen_US
Keywordsdc.subjectUptake Systemen_US
Keywordsdc.subjectFunctional-Analysisen_US
Keywordsdc.subjectEscherichia-Colien_US
Keywordsdc.subjectGene- Expressionen_US
Keywordsdc.subjectBindingen_US
Keywordsdc.subjectProteinen_US
Keywordsdc.subjectNetworksen_US
Keywordsdc.subjectPathogenen_US
Títulodc.titleInterplay between copper and zinc homeostasis through the transcriptional regulator Zur in Enterococcus faecalisen_US
Document typedc.typeArtículo de revista


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