The Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamine
Riveros, Maria E.
Aedo Sánchez, Cristian
Valdés, José L.
Cita de ítem
PLOS ONE Volumen: 11 Número: 2 Número de artículo: e0148484 (2016)
Artículo de publicación ISI
The histaminergic system is one component of the ascending arousal system which is
involved in wakefulness, neuroendocrine control, cognition, psychiatric disorders and motivation.
During the appetitive phase of motivated behaviors the arousal state rises to an optimal
level, thus giving proper intensity to the behavior. Previous studies have demonstrated
that the histaminergic neurons show an earlier activation during the appetitive phase of
feeding, compared to other ascending arousal system nuclei, paralleled with a high
increase in arousal state. Lesions restricted to the histaminergic neurons in rats reduced
their motivation to get food even after 24h of food deprivation, compared with intact or sham
lesioned rats. Taken together, these findings indicate that the histaminergic system is
important for appetitive behavior related to feeding. However, its role in other goal-directed
behaviors remains unexplored. In the present work, male rats rendered motivated to obtain
water, sex, or amphetamine showed an increase in Fos-ir of histaminergic neurons in appetitive
behaviors directed to get those reinforcers. However, during appetitive tests to obtain
sex, or drug in amphetamine-conditioned rats, Fos expression increased in most other
ascending arousal system nuclei, including the orexin neurons in the lateral hypothalamus,
dorsal raphe, locus coeruleus and laterodorsal tegmental neurons, but not in the ventral tegmental
area, which showed no Fos-ir increase in any of the 3 conditions. Importantly, all
these appetitive behaviors were drastically reduced after histaminergic cell-specific lesion,
suggesting a critical contribution of histamine on the intensity component of several appetitive
Fondecyt; Programa de Investigacion Asociativa, Anillos; Iniciativa Cientifica Milenio, Ministerio de Economia.