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The Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamine

Authordc.contributor.authorContreras, Marco 
Authordc.contributor.authorRiveros, Maria E. 
Authordc.contributor.authorQuispe, Maricel 
Authordc.contributor.authorAedo Sánchez, Cristian 
Authordc.contributor.authorPerdomo, Guayec 
Authordc.contributor.authorTorrealba, Fernando 
Authordc.contributor.authorValdés, José L. 
Cita de ítemdc.identifier.citationPLOS ONE Volumen: 11 Número: 2 Número de artículo: e0148484 (2016)en_US
Identifierdc.identifier.otherDOI: 10.1371/journal.pone.0148484
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractThe histaminergic system is one component of the ascending arousal system which is involved in wakefulness, neuroendocrine control, cognition, psychiatric disorders and motivation. During the appetitive phase of motivated behaviors the arousal state rises to an optimal level, thus giving proper intensity to the behavior. Previous studies have demonstrated that the histaminergic neurons show an earlier activation during the appetitive phase of feeding, compared to other ascending arousal system nuclei, paralleled with a high increase in arousal state. Lesions restricted to the histaminergic neurons in rats reduced their motivation to get food even after 24h of food deprivation, compared with intact or sham lesioned rats. Taken together, these findings indicate that the histaminergic system is important for appetitive behavior related to feeding. However, its role in other goal-directed behaviors remains unexplored. In the present work, male rats rendered motivated to obtain water, sex, or amphetamine showed an increase in Fos-ir of histaminergic neurons in appetitive behaviors directed to get those reinforcers. However, during appetitive tests to obtain sex, or drug in amphetamine-conditioned rats, Fos expression increased in most other ascending arousal system nuclei, including the orexin neurons in the lateral hypothalamus, dorsal raphe, locus coeruleus and laterodorsal tegmental neurons, but not in the ventral tegmental area, which showed no Fos-ir increase in any of the 3 conditions. Importantly, all these appetitive behaviors were drastically reduced after histaminergic cell-specific lesion, suggesting a critical contribution of histamine on the intensity component of several appetitive behaviors.en_US
Patrocinadordc.description.sponsorshipFondecyt; Programa de Investigacion Asociativa, Anillos; Iniciativa Cientifica Milenio, Ministerio de Economia.en_US
Publisherdc.publisherPUBLIC LIBRARY SCIENCEen_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjecthypothalamic neuronsen_US
Keywordsdc.subjecttuberomammillary nucleusen_US
Títulodc.titleThe Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamineen_US
Document typedc.typeArtículo de revistaen_US

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile