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Acute Copper and Ascorbic Acid Supplementation Inhibits Non-heme Iron Absorption in Humans

Authordc.contributor.authorOlivares Grohnert, Manuel 
Authordc.contributor.authorFigueroa Donoso, Constanza 
Authordc.contributor.authorPizarro Aguirre, Fernando 
Admission datedc.date.accessioned2017-01-04T19:23:28Z
Available datedc.date.available2017-01-04T19:23:28Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationBiol Trace Elem Res (2016) 172:315–319es_ES
Identifierdc.identifier.other10.1007/s12011-015-0605-z
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/142260
Abstractdc.description.abstractThe objective of the study is to determine the effect of copper (Cu) plus the reducing agent ascorbic acid (AA) on the absorption of non-heme iron (Fe). Experimental study with block design in which each subject was his own control. After signing an informed consent, 14 adult women using an effective method of contraception and negative pregnancy test received 0.5 mg Fe, as ferrous sulfate, alone or with Cu, as copper sulfate, plus ascorbic acid (AA/Cu 2/1 molar ratio) at 4/1; 6/1 and 8/1 Cu/Fe molar ratios as an aqueous solution on days 1, 2, 14, and 15 of the study. Fe absorption was assessed by erythrocyte incorporation of iron radioisotopes Fe-55 and Fe-59. Geometric mean (range +/- SD) absorption of Fe at 4/1 and 6/1 Cu/Fe molar ratios (and AA/Cu 2/1 molar ratio) and Fe alone was 57.4 % (35.7-92.1 %), 64.2 % (45.8-89.9 %), and 38.8%(20.4-73.8 %), respectively (ANOVA for repeated measures p<0.001; post hoc test Scheff, p<0.05). This is attributable to the enhancing effect of AA on non-heme Fe absorption; however, Fe absorption at Cu/Fe 8/1 molar ratio was 47.3% (27.7-80.8) (p=NS compared with Fe alone). It was expected that Fe absorption would have been equal or greater than at 4/1 and 6/1 molar ratios. Copper in the presence of ascorbic acid inhibits non-heme Fe absorption at Cu/Fe 8/1 molar ratioes_ES
Patrocinadordc.description.sponsorshipFONDECYT-Chile 1130075es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherHumana Presses_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceBiological Trace Element Researches_ES
Keywordsdc.subjectIron absorptiones_ES
Keywordsdc.subjectIrones_ES
Keywordsdc.subjectCopperes_ES
Keywordsdc.subjectAscorbic acides_ES
Keywordsdc.subjectHumanses_ES
Títulodc.titleAcute Copper and Ascorbic Acid Supplementation Inhibits Non-heme Iron Absorption in Humanses_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorapces_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile