Antibody and B Cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis
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The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.
Artículo de publicación ISI
Quote ItemOpen Forum Infectious Diseases Volumen: 5 Número: 1 Número de artículo: UNSP ofx255
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