The influence of diet on liver phosphorylase. II. Effect of different proportions of carbohydrates, proteins and fats
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Liver phosphorylase activity was found to be proportional to the caloric intake of the animal. Rats fed for 6 or 10 days an exclusively carbohydrate diet showed a phosphorylase content of the liver similar to animals fed isocaloric amounts of equilibrated diet, in spite of the protein depletion. The same results were observed with fat-free carbohydrate diets containing variable proportions of casein. The phosphorylase activity decreased markedly in rats kept on carbohydrate-free, high-fat diets, containing as much protein as 25% of the total calories. The diminution of the enzyme content was observed even after only 1 day on the high-fat diet. The rate of increase in liver phosphorylase, after a decrease provoked by a 48-hr, fasting, was the same in animals subsequently fed an equilibrated diet or carbohydrates alone. In the latter conditions the liver proteins remained at the same low levels as during fasting. © 1962.
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