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Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe 2+

Authordc.contributor.authorGarcía Beltrán, Olimpo 
Authordc.contributor.authorMena, Natalia 
Authordc.contributor.authorYañez, Osvaldo 
Authordc.contributor.authorCaballero, Julio 
Authordc.contributor.authorVargas, Víctor 
Authordc.contributor.authorNúñez González, Marco 
Authordc.contributor.authorCassels Niven, Bruce 
Admission datedc.date.accessioned2018-12-20T14:13:57Z
Available datedc.date.available2018-12-20T14:13:57Z
Publication datedc.date.issued2013
Cita de ítemdc.identifier.citationEuropean Journal of Medicinal Chemistry, Volumen 67,
Identifierdc.identifier.issn17683254
Identifierdc.identifier.issn02235234
Identifierdc.identifier.other10.1016/j.ejmech.2013.06.022
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/155040
Abstractdc.description.abstractA new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3- dihydroxy-2-(hydroxymethyl) propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe 2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. © 2013 Elsevier Masson SAS. All rights reserved.
Lenguagedc.language.isoen
Publisherdc.publisherElsevier Masson SAS
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceEuropean Journal of Medicinal Chemistry
Keywordsdc.subjectFluorescent sensor
Keywordsdc.subjectMolecular dynamics
Keywordsdc.subjectTurn-off probes
Títulodc.titleDesign, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe 2+
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile