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Authordc.contributor.authorNúñez González, Marco 
Authordc.contributor.authorTapia, Victoria 
Authordc.contributor.authorArredondo, Miguel 
Admission datedc.date.accessioned2018-12-20T14:41:23Z
Available datedc.date.available2018-12-20T14:41:23Z
Publication datedc.date.issued1996
Cita de ítemdc.identifier.citationJournal of Nutrition, Volumen 126, Issue 9, 2018, Pages 2151-2158
Identifierdc.identifier.issn00223166
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/157075
Abstractdc.description.abstractAlthough the absorption of iron through the intestinal epithelia is inversely related to body iron stores, the mechanisms by which the enterocytes sense body iron stores are unknown. Polarized enterocytes have transferrin receptors in their basolateral surface; hence, we tested the hypothesis that the endocytosis of circulating transferrin may be part of the body's iron sensing mechanism. Particularly, we evaluated the contribution of basolateral transferrin to iron content of intestinal cells, and we investigated what factors modulate this contribution. For this purpose, we used the intestinal cell line Caco-2 grown on porous filters. When the cells were simultaneously offered equimolar amounts of iron, from the apical medium as 55Fe-nitrilotriacetate and from the basolateral medium as 59Fe- transferrin, most of the internalized iron came from the basolateral endocytosis of 59Fe-transferrin. Experiments of transferrin binding and internalization showed that holotransferrin and apotran
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Nutrition
Keywordsdc.subjectapotransferrin
Keywordsdc.subjectCaco-2 cells
Keywordsdc.subjectenterocyte
Keywordsdc.subjectiron absorption
Keywordsdc.subjecttransferrin receptor
Títulodc.titleIntestinal epithelia (Caco-2) cells acquire iron through the basolateral endocytosis of transferrin
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile