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A cyclized peptide derived from α fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells

Authordc.contributor.authorTorres, Cristian 
Authordc.contributor.authorPino Zúñiga, Ana María 
Authordc.contributor.authorSierralta Lundin, Walter 
Admission datedc.date.accessioned2018-12-20T14:52:37Z
Available datedc.date.available2018-12-20T14:52:37Z
Publication datedc.date.issued2009
Cita de ítemdc.identifier.citationOncology Reports, Volumen 21, Issue 6, 2009, Pages 1397-1404
Identifierdc.identifier.issn1021335X
Identifierdc.identifier.issn17912431
Identifierdc.identifier.other10.3892/or_00000367
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157148
Abstractdc.description.abstractThe effects of estradiol (E2) and of an AFP-derived cyclized peptide (cP) on the proliferation of primary cultures of cancer cells isolated from spontaneous canine mammary tumors were studied. The cellular response to E2 and cP was related to the expression of estradiol receptor (isoforms α and β). In ER-positive cells, 2 nM estradiol increased cell proliferation and the phosphorylation of ERK1/2; 2 μg/ml cP inhibited all these effects. Estradiol also increased HER2 immunoreactivity in ER-positive cells, an effect that was reverted to its basal values by cP. Estradiol stimulated in these cells the release of MMP2 and MMP9 and the shedding of HB-EGF, effects that the cP did not affect. ER-negative cells were refractory to estradiol or cP. All canine mammary tumor cells in culture responded to treatments analogously to human mammary cancer cells. Our results support the proposal of cP as a new, potentially effective therapeutic agent for the management of mammary cancer.
Lenguagedc.language.isoen
Sourcedc.sourceOncology Reports
Keywordsdc.subjectα fetoprotein
Keywordsdc.subjectCanine mammary cancer cells
Keywordsdc.subjectCyclized peptide
Keywordsdc.subjectEstradiol
Keywordsdc.subjectHER2/neu
Títulodc.titleA cyclized peptide derived from α fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorapc
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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