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Synthesis, characterization and in vitro antifungal evaluation of novel benzimidazo [1,2-c]quinazolines

Authordc.contributor.authorInsuasty, B. A. 
Authordc.contributor.authorTorres, H. 
Authordc.contributor.authorQuiroga, J. 
Authordc.contributor.authorAbonía, R. 
Authordc.contributor.authorRodríguez, R. 
Authordc.contributor.authorNogeras, M. 
Authordc.contributor.authorSánchez, A. 
Authordc.contributor.authorSaitz, C. 
Authordc.contributor.authorAlvarez, S. L. 
Authordc.contributor.authorZacchino, S. A. 
Admission datedc.date.accessioned2018-12-20T15:04:13Z
Available datedc.date.available2018-12-20T15:04:13Z
Publication datedc.date.issued2006
Cita de ítemdc.identifier.citationJournal of the Chilean Chemical Society, Volumen 51, Issue 2, 2018, Pages 927-932
Identifierdc.identifier.issn07179324
Identifierdc.identifier.issn07179324
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157497
Abstractdc.description.abstractThe synthesis of a series of new benzimidazo[1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is described. The structure elucidation of the products is based on detailed NMR analysis of experiments such as 1H-COSY, NOESY, DEPT, HSQC and HMBC. These compounds showed antifungal properties only against dermatophytes. Among them, those with electron-donor substituents on the 6-phenyl ring inhibited mainly T. rubrum and E. floccosum with MICs between 25-250 μg/mL and M. canis, M. gypseum and T. mentagrophytes with MICs between 50-250 μg/mL. Structures with electron-withdrawing substituents on the phenyl ring did not show any activities up to 250 μg/ml. Methyl substituents on the benzimidazole ring seem negatively affect the antifungal behaviour of this series. © 2006 Sociedad Chilena de Química.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of the Chilean Chemical Society
Keywordsdc.subjectAntifungal evaluation
Keywordsdc.subjectBenzimidazo[1,2-c]quinazolines
Keywordsdc.subjectBenzimidazoles
Keywordsdc.subjectDermatophytes
Keywordsdc.subjectQuinazolines
Títulodc.titleSynthesis, characterization and in vitro antifungal evaluation of novel benzimidazo [1,2-c]quinazolines
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile