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Differential prooxidative effect of adult and fetal hemoglobin

Authordc.contributor.authorValenzuela Bonomo, Carlos 
Authordc.contributor.authorGuerra, Ricardo 
Authordc.contributor.authorLazcano, Laura 
Authordc.contributor.authorCanãs, Patricio 
Admission datedc.date.accessioned2018-12-20T15:05:08Z
Available datedc.date.available2018-12-20T15:05:08Z
Publication datedc.date.issued1986
Cita de ítemdc.identifier.citationFEBS Letters, Volumen 196, Issue 2, 2018, Pages 353-356
Identifierdc.identifier.issn00145793
Identifierdc.identifier.other10.1016/0014-5793(86)80278-2
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157686
Abstractdc.description.abstractHuman fetal hemoglobin assayed in a peroxidizing system shows an increased prooxidative effect when compared to human adult hemoglobin. This effect is related only to the oxyhemoglobin form since both fetal and adult methemoglobins did not show any prooxidative effect. The prooxidative effect of the oxyhemoglobin form is ascribed to its increased sensitivity to form Superoxide free radicals when transformed to the methemoglobin form. It is proposed that the structure of the heme pocket of fetal oxyhemoglobin enhances free radical release when compared to adult oxyhemoglobin. This difference may be important in some hematological disorders presented by the newborn. © 1986.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceFEBS Letters
Keywordsdc.subjectBiochemistry
Keywordsdc.subjectBiophysics
Keywordsdc.subjectMolecular Biology
Títulodc.titleDifferential prooxidative effect of adult and fetal hemoglobin
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile