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Polarographic behaviour and determination of ranitidine in pharmaceutical formulations and urine

Authordc.contributor.authorRichter Duk, Pablo 
Authordc.contributor.authorToral Ponce, María 
Authordc.contributor.authorMuñoz-Vargas, Fernando 
Admission datedc.date.accessioned2018-12-20T15:09:13Z
Available datedc.date.available2018-12-20T15:09:13Z
Publication datedc.date.issued1994
Cita de ítemdc.identifier.citationThe Analyst, Volumen 119, Issue 6, 1994, Pages 1371-1374
Identifierdc.identifier.issn00032654
Identifierdc.identifier.other10.1039/AN9941901371
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157977
Abstractdc.description.abstractA polarographic method for the determination of ranitidine is described, based on the reduction of the nitro group at a dropping-mercury electrode. The proposed method permits the drug to be determined, without any prior separation or extraction, in pharmaceutical formulations and urine at levels at which the unchanged drug is excreted. The current is diffusion controlled and proportional to concentration from 3.58 X 10(-3) to 1.50 mmol l(-1). The detection limit is 1.07 X 10(-3) mmol l(-1). The reduction process was studied at different pH values and a reduction mechanism is proposed in which the importance of the homogeneous chemical reactions associated with the electron-transfer steps are indicated.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceThe Analyst
Keywordsdc.subjectAnalytical chemistry
Keywordsdc.subjectEnvironmental chemistry
Keywordsdc.subjectBiochemistry
Keywordsdc.subjectSpectroscopy
Keywordsdc.subjectElectrochemistry
Títulodc.titlePolarographic behaviour and determination of ranitidine in pharmaceutical formulations and urine
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorrvh
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile