Electrochemical study of the nitro radical anion from nicardipine: Kinetic parameters and its interaction with glutathione

Abstract

The cyclic voltammetric behavior of nicardipine was studied. Particular attention was directed to the one-electron ArNO2/ArNO2•- couple as measured by the cyclic voltammetric mode in aqueous DMF mixed media. Analysis of this response as a function of scan rate yields information on the stability of the nitro radical anion. A second-order rate constant k2 = 174 1 mol-1 s-1 for the decomposition of the nitro radical anion from nicardipine and a half-life of 1.15 s were obtained. The cyclic voltammetric technique was also employed to study the tendency of ArNO2•- to undergo further chemical reaction; specific attention was paid to the interaction with glutathione. © 1994.