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Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity

Authordc.contributor.authorVieites, Marisol 
Authordc.contributor.authorOtero, Lucía 
Authordc.contributor.authorSantos, Diego 
Authordc.contributor.authorOlea Azar, Claudio 
Authordc.contributor.authorNorambuena, Ester 
Authordc.contributor.authorAguirre, Gabriela 
Authordc.contributor.authorCerecetto, Hugo 
Authordc.contributor.authorGonzález, Mercedes 
Authordc.contributor.authorKemmerling Weis, Ulrike 
Authordc.contributor.authorMorello, Antonio 
Authordc.contributor.authorMaya Arango, Juan 
Authordc.contributor.authorGambino, Dinorah 
Admission datedc.date.accessioned2018-12-20T15:10:05Z
Available datedc.date.available2018-12-20T15:10:05Z
Publication datedc.date.issued2009
Cita de ítemdc.identifier.citationJournal of Inorganic Biochemistry, Volumen 103, Issue 3, 2018, Pages 411-418
Identifierdc.identifier.issn01620134
Identifierdc.identifier.other10.1016/j.jinorgbio.2008.12.004
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158136
Abstractdc.description.abstractEight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the micromolar range against two different strains of Trypanosoma cruzi, causative agent of Chagas disease (American Trypanosomiasis). In addition, most of the newly developed complexes, together with the analogous platinum 5-nitrofuraldehyde containing thiosemicarbazones previously reported, resulted more active than the reference trypanocidal drug nifurtimox on the infective trypomastigote form of the parasite. Their capacity to produce free radicals that could lead to parasite death was evaluated by ESR experiments in the parasite and by respiration measurements. Compounds were tested for their DNA interaction ability. Results showed that some of the compounds could act as dual inhibitors in the parasite, through production of toxic free radicals and interaction with D
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Inorganic Biochemistry
Keywordsdc.subject5-Nitrofuryl containing thiosemicarbazones
Keywordsdc.subjectChagas disease
Keywordsdc.subjectPlatinum
Keywordsdc.subjectTrypanosoma cruzi
Títulodc.titlePlatinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile