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Molecular encapsulation of 5-nitroindazole derivatives in 2,6-dimethyl-β-cyclodextrin: Electrochemical and spectroscopic studies

Authordc.contributor.authorPérez Cruz, Fernanda 
Authordc.contributor.authorJullian Matthaei, Carolina 
Authordc.contributor.authorRodriguez, Jorge 
Authordc.contributor.authorArán, Vicente J. 
Authordc.contributor.authorOlea Azar, Claudio 
Admission datedc.date.accessioned2018-12-20T15:10:07Z
Available datedc.date.available2018-12-20T15:10:07Z
Publication datedc.date.issued2009
Cita de ítemdc.identifier.citationBioorganic and Medicinal Chemistry, Volumen 17, Issue 13, 2018, Pages 4604-4611
Identifierdc.identifier.issn09680896
Identifierdc.identifier.other10.1016/j.bmc.2009.04.067
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158150
Abstractdc.description.abstractFour different 5-nitroindazole derivatives (1-4) and its inclusion with Heptakis(2,6-di-O-methyl)-β-cyclodextrin (DMβCD) were investigated. The stoichiometric ratios and stability constants describing the extent of formation of the complexes were determined by phase-solubility measurements obtaining in all cases a type-AL diagram. Also electrochemical studies were carried out, where the observed change in the EPC value indicated a lower feasibility of the nitro group reduction. The same behavior was observed in the ESR studies. The detailed spatial configuration is proposed based on 2D NMR methods. These results are further interpreted using molecular modeling studies. The latter results are in good agreement with the experimental data. © 2009 Elsevier Ltd. All rights reserved.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBioorganic and Medicinal Chemistry
Keywordsdc.subject5-Nitroindazole
Keywordsdc.subjectCyclodextrin
Keywordsdc.subjectESR
Keywordsdc.subjectMolecular modeling
Keywordsdc.subjectNMR
Títulodc.titleMolecular encapsulation of 5-nitroindazole derivatives in 2,6-dimethyl-β-cyclodextrin: Electrochemical and spectroscopic studies
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile