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Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae

Authordc.contributor.authorMuñoz Muñoz, Orlando 
Authordc.contributor.authorChristen, Philippe 
Authordc.contributor.authorCretton, Sylvian 
Authordc.contributor.authorBackhouse, Nadine 
Authordc.contributor.authorTorres, Vanessa 
Authordc.contributor.authorCorrea, Olosmira 
Authordc.contributor.authorCosta, Edda 
Authordc.contributor.authorMiranda, Hugo 
Authordc.contributor.authorDelporte, Carla 
Admission datedc.date.accessioned2018-12-20T15:10:30Z
Available datedc.date.available2018-12-20T15:10:30Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationJournal of Pharmacy and Pharmacology, Volumen 63, Issue 6, 2018, Pages 849-859
Identifierdc.identifier.issn00223573
Identifierdc.identifier.issn20427158
Identifierdc.identifier.other10.1111/j.2042-7158.2011.01280.x
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158213
Abstractdc.description.abstractObjectives Aristotelia chilensis leaves (Elaeocarpaceae) are used in Chilean folk medicine to treat pain and inflammation. A bioguided study was carried out on serial extracts (hexane, dichloromethane, methanol, aqueous extract (INFU) and a crude mixture of alkaloids (ALK-MIX). All extracts were evaluated for (1) topical administration against both arachidonic acid and 12-deoxyphorbol-13-decanoate (TPA)-induced inflammation in mice and (2) per-os administration against inflammation by λ-carrageenan-induced paw oedema in guinea-pigs and (3) topical analgesia in tail flick and formalin models and per-os writhing test in mice. Methods Greater anti-inflammatory effects were obtained against TPA with dichloromethane extract and methanol extract (63.9 and 66.0%, respectively). INFU showed the most potent effect (56.2%) against arachidonic acid. Greater effects were obtained in the writhing test with hexane and dichloromethane extracts (89.2% both). In the topical analgesia models, all the ex
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Pharmacy and Pharmacology
Keywordsdc.subjectalkaloids
Keywordsdc.subjectAristotelia chilensis
Keywordsdc.subjectflavonoids
Keywordsdc.subjecttriterpenes
Títulodc.titleChemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile