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Voltammetric Determination of Nifedipine on Carbon Nanotubes-Modified Glassy Carbon Electrode: A new Application to Dissolution Test Studies

Authordc.contributor.authorJara Ulloa, Paola Andrea 
Authordc.contributor.authorSalgado Figueroa, Paola 
Authordc.contributor.authorYañez, 
Authordc.contributor.authorNúñez Vergara, Luis 
Authordc.contributor.authorSquella Serrano, Juan 
Admission datedc.date.accessioned2018-12-20T15:10:54Z
Available datedc.date.available2018-12-20T15:10:54Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationElectroanalysis, Volumen 24, Issue 8, 2018, Pages 1751-1757
Identifierdc.identifier.issn10400397
Identifierdc.identifier.issn15214109
Identifierdc.identifier.other10.1002/elan.201200184
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158294
Abstractdc.description.abstractWe report the adsorptive voltammetric determination of nifedipine on multiwalled carbon nanotubes (MWCNT)-modified glassy carbon electrode (GCE). Nifedipine was adsorbed on the MWCNT and then reduced using linear sweep and cyclic voltammetry (LSV and CV). Parameters such as pH and accumulation time were tested. The MWCNT-modified GCE showed enhanced currents and good signal-to-noise characteristics in comparison with the bare GCE. Consecutive measurements with the modified electrode were highly repeatable and reproducible. The MWCNT/GCE was used for the determination of nifedipine and is recommended for quantitation in dissolution test studies. In this study we have tested normal and extended-release pharmaceutical formulations of nifedipine using USP apparatus 2 and tracking the released drug in solution by the proposed voltammetric method. The main advantage of the voltammetric determination is the feasibility to detect the drug in-situ avoiding tedious intermediate steps such as fil
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceElectroanalysis
Keywordsdc.subjectCarbon nanotubes
Keywordsdc.subjectDissolution test
Keywordsdc.subjectNifedipine
Keywordsdc.subjectVoltammetry
Títulodc.titleVoltammetric Determination of Nifedipine on Carbon Nanotubes-Modified Glassy Carbon Electrode: A new Application to Dissolution Test Studies
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile