Show simple item record

Capping gold nanoparticles with modified chitosan polymers for biomedical applications

Authordc.contributor.authorMena, Juan F. 
Authordc.contributor.authorNeira Carrillo, Andrónico 
Authordc.contributor.authorYazdani-Pedram Zobeiri, Mehrdad 
Authordc.contributor.authorKogan Bocian, Marcelo 
Admission datedc.date.accessioned2018-12-20T15:10:55Z
Available datedc.date.available2018-12-20T15:10:55Z
Publication datedc.date.issued2013
Cita de ítemdc.identifier.citationJournal of Biomaterials and Tissue Engineering, Volumen 3, Issue 1, 2018, Pages 135-140
Identifierdc.identifier.issn21579091
Identifierdc.identifier.issn21579083
Identifierdc.identifier.other10.1166/jbt.2013.1072
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158304
Abstractdc.description.abstractWith the purpose of obtaining stable and non-toxic nanocomposites with potential biomedical applications we coated gold nanoparticles (AuNP) with chitosan (CHI) and CHI grafted with poly(Nisopropilacrylamide) (PNIPAAm) and poly(N,N-dimethylacrylamide) (PDMAAm). We used a grafting reaction carried out by free radical initiation mechanism using potassium persulfate. We characterized the grafted CHI by FT-IR and thermogravimetry, grafting parameters were also calculated. Gold nanoparticles (AuNP) were obtained by reduction of the auric salt with citrate. Nanocomposites were obtained by mixing dropwise polymer solution into a AuNP solution under intense stirring, with variable AuNP:copolymer ratios. These were characterized using UV-Visible spectrophotometry and transmission electronic microscopy (TEM). The effects on cell viability of neuroblastoma SHSY-5Y cells were evaluated performing the MTT assay. CHI and the grafted CHI with PNIPA did not show effects on cell viability while PDMA pr
Lenguagedc.language.isoen
Publisherdc.publisherAmerican Scientific Publishers
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Biomaterials and Tissue Engineering
Keywordsdc.subjectChitosan
Keywordsdc.subjectDrug delivery
Keywordsdc.subjectGold nanoparticles
Keywordsdc.subjectNanotoxicology
Títulodc.titleCapping gold nanoparticles with modified chitosan polymers for biomedical applications
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile