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Spectral study and simultaneous determination of sulfamethoxazole and trimethoprim by digital derivative spectrophotometry Estudio espectral y determinación simultanea de sulfametoxazol y trimetoprim por espectrofotometría derivada digital

Authordc.contributor.authorToral Ponce, María 
Authordc.contributor.authorLara, Nelson 
Authordc.contributor.authorTapia, A. Eugenia 
Authordc.contributor.authorTorres, Claudio 
Authordc.contributor.authorRichter Duk, Pablo 
Admission datedc.date.accessioned2018-12-20T15:20:44Z
Available datedc.date.available2018-12-20T15:20:44Z
Publication datedc.date.issued2002
Cita de ítemdc.identifier.citationBoletin de la Sociedad Chilena de Quimica, Volumen 47, Issue 3, 2018, Pages 241-251
Identifierdc.identifier.issn03661644
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158890
Abstractdc.description.abstractA direct and simple second derivative digital spectrophometric method has been developed for the simultaneous determination of the sulfamethoxazole and trimethoprim in pharmaceutical formulation. A study of the spectral behavior of these drugs in different solvents is included, in order to select the best conditions for their simultaneous determination. Acetonitrile was used as solvent to extract the drugs from the pharmaceutical formulations and then to evaluate directly by second derivative spectra. This sumultaneous determination was carried out by the zero crossing approach, at 272,8 nm for sulfamethoxazole determination and at 256,0 nm for trimethoprim determination. The determination range for sulfamethoxazole was from 6,31×10-8 to 1,2×x10-4 mol/L and for trimethoprim from 2,47×10-7 to 1,20×10-4 mol/L, and the detection limits for sulfamethoxazole and trimethoprim were 1,89×10-8 mol/L and 7,40×10-8 mol/L, respectively. The method was applied successfully in pharmaceutical formula
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBoletin de la Sociedad Chilena de Quimica
Keywordsdc.subjectDerivative spectrophotometry
Keywordsdc.subjectPharmaceutical Formulations
Keywordsdc.subjectSpectral study
Keywordsdc.subjectSulfamethoxazole and Trimethoprim
Títulodc.titleSpectral study and simultaneous determination of sulfamethoxazole and trimethoprim by digital derivative spectrophotometry Estudio espectral y determinación simultanea de sulfametoxazol y trimetoprim por espectrofotometría derivada digital
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile