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Major histocompatibility system as a risk factor for alcoholic liver disease El sistema mayor de histocompatibilidad como factor de riesgo de la enfermedad hepática alcohólica.

Authordc.contributor.authorLlop Romero, Elena 
Authordc.contributor.authorHirsch Birn, Sandra 
Authordc.contributor.authorMaza Cave, María Pía de la 
Authordc.contributor.authorBunout Barnett, Daniel 
Authordc.contributor.authorIturriaga, 
Authordc.contributor.authorSilva Silva, Laura 
Authordc.contributor.authorUgarte, 
Authordc.contributor.authorRothhammer Engel, Francisco 
Admission datedc.date.accessioned2019-01-29T14:14:03Z
Available datedc.date.available2019-01-29T14:14:03Z
Publication datedc.date.issued1995
Cita de ítemdc.identifier.citationRevista médica de Chile, Volumen 123, Issue 6, 2018, Pages 687-693
Identifierdc.identifier.issn00349887
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/160307
Abstractdc.description.abstractSeveral associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and change from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among Chilean alcoholics. We studied blood groups, serum proteins and HLA antigens in 39 alcoholic cirrhotics, 104 asymptomatic alcoholics and 44 non alcoholic controls. Asymptomatic alcoholics were also subjected to a percutaneous liver biopsy that showed moderate to severe histological liver damage in 46 subjects (44%). No differences in the studied genetic markers, were found among the four groups. It is concluded that this study does not confirm previously reported associations between genetic markers and alcoholic liver disease.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceRevista médica de Chile
Keywordsdc.subjectMedicine (all)
Títulodc.titleMajor histocompatibility system as a risk factor for alcoholic liver disease El sistema mayor de histocompatibilidad como factor de riesgo de la enfermedad hepática alcohólica.
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile