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Effect of melatonin on rat spinal cord nociceptive transmission

Authordc.contributor.authorLaurido, Claudio 
Authordc.contributor.authorPelissier Serrano, Teresa 
Authordc.contributor.authorSoto Moyano, Rubén 
Authordc.contributor.authorLópez Valladares, Luis 
Authordc.contributor.authorFlores, Francisco 
Authordc.contributor.authorHernández, Alejandro 
Admission datedc.date.accessioned2019-01-29T17:51:55Z
Available datedc.date.available2019-01-29T17:51:55Z
Publication datedc.date.issued2002
Cita de ítemdc.identifier.citationNeuroReport, Volumen 13, Issue 1, 2018, Pages 89-91
Identifierdc.identifier.issn09594965
Identifierdc.identifier.other10.1097/00001756-200201210-00021
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/163607
Abstractdc.description.abstractMelatonin has been shown to exert potent antinociception but the sites and mechanisms of action underlying this effect have not yet been clarified. The effect of melatonin on spinal cord nociceptive transmission was studied in rats by assessing wind-up activity in a C-fiber reflex responses paradigm evoked by repetitive (0.6 Hz) electric stimulation. Intraperitoneal administration of 1.25, 2.5, 5.0 and 10.0 mg/kg melatonin induced a dose-dependent inhibition of spinal wind-up activity, the higher dose of the drug used being able to depress completely the C reflex gain. Results indicate that melatonin markedly depresses spinal wind-up in rats, probably through hyperpolarization of dorsal horn neurons consecutive to melatonin binding to membrane receptors, and/or via intracellular interference with a NMDA receptor-dependent nitric oxide generating pathway. © 2002 Lippincott Williams & Wilkins.
Lenguagedc.language.isoen
Publisherdc.publisherLippincott Williams and Wilkins
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceNeuroReport
Keywordsdc.subjectAntinociception
Keywordsdc.subjectC-fiber reflex
Keywordsdc.subjectMelatonin
Keywordsdc.subjectPain
Keywordsdc.subjectRat
Keywordsdc.subjectSpinal cord
Keywordsdc.subjectWind-up
Títulodc.titleEffect of melatonin on rat spinal cord nociceptive transmission
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile