Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia
Author
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Martínez Aguayo, Alejandro
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Rocha, A.
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Rojas, N.
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García, C.
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Parra R., Bélgica
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Lagos, M.
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Valdivia, L.
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Poggi, H.
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Cattani, Andreína
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Alcazar, M. L.
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Lacourt, P.
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Cassorla Goluboff, Fernando
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Codner Dujovne, Ethel
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Escobar, E.
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Gaete, X.
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García, H.
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Silva, R.
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Giadrosich, V.
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Godoy, C.
Author
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Ugarte,
Admission date
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2019-03-11T12:55:03Z
Available date
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2019-03-11T12:55:03Z
Publication date
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2007
Cita de ítem
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Journal of Clinical Endocrinology and Metabolism, Volumen 92, Issue 12, 2018, Pages 4583-4589
Identifier
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0021972X
Identifier
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0021972X
Identifier
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10.1210/jc.2007-0383
Identifier
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https://repositorio.uchile.cl/handle/2250/164443
Abstract
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Context: Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been associated with testicular adrenal rest tumors (TART) that may originate during childhood. Objective: Our objective was to describe the prevalence of TART and Sertoli and Leydig cell function in a group of boys aged 2-10 yr with CAH and to compare prevalence with that of a control group. Design: From August 2005 to January 2007, 19 patients with classical CAH (CAH group) were referred from seven endocrinology centers. Methods: We studied 19 subjects in the CAH group and, as a control group, 13 boys from the community that did not have testicular diseases. A complete physical exam was performed. High-resolution ultrasound was used to determine TART prevalence. Inhibin B and anti-Müllerian hormone were used as Sertoli cell markers. The ratio between basal testosterone levels and testosterone levels 72 h after β-human chorionic gonadotropin (5000 U/m2) treatment [(T72- T 0)/T0] was used to eval