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Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox

Authordc.contributor.authorFaúndez, Mario 
Authordc.contributor.authorLópez Muñoz, Rodrigo 
Authordc.contributor.authorTorres, Gloria 
Authordc.contributor.authorMorello, Antonio 
Authordc.contributor.authorFerreira, Jorge 
Authordc.contributor.authorKemmerling Weis, Ulrike 
Authordc.contributor.authorOrellana, Myriam 
Authordc.contributor.authorMaya Arango, Juan 
Admission datedc.date.accessioned2019-03-11T12:55:47Z
Available datedc.date.available2019-03-11T12:55:47Z
Publication datedc.date.issued2008
Cita de ítemdc.identifier.citationAntimicrobial Agents and Chemotherapy, Volumen 52, Issue 5, 2018, Pages 1837-1839
Identifierdc.identifier.issn00664804
Identifierdc.identifier.other10.1128/AAC.01454-07
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/164509
Abstractdc.description.abstractL-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts. Treatment with BSO plus nifurtimox caused an increase in the survival rate in comparison to the rates with treatment with each drug alone. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceAntimicrobial Agents and Chemotherapy
Keywordsdc.subjectPharmacology
Keywordsdc.subjectPharmacology (medical)
Keywordsdc.subjectInfectious Diseases
Títulodc.titleButhionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile