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Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome

Authordc.contributor.authorSir Petermann, Teresa 
Authordc.contributor.authorCodner Dujovne, Ethel 
Authordc.contributor.authorPérez, Virginia 
Authordc.contributor.authorEchiburú López, Bárbara 
Authordc.contributor.authorMaliqueo Yevilao, Manuel 
Authordc.contributor.authorLadrón de Guevara, Amanda 
Authordc.contributor.authorPreisler, Jessica 
Authordc.contributor.authorCrisosto King, Nicolás 
Authordc.contributor.authorSánchez, Fernando 
Authordc.contributor.authorCassorla Goluboff, Fernando 
Authordc.contributor.authorBhasin, Shalender 
Cita de ítemdc.identifier.citationJournal of Clinical Endocrinology and Metabolism, Volumen 94, Issue 6, 2018, Pages 1923-1930
Abstractdc.description.abstractContext: A significant proportion of the first-degree female relatives of women with polycystic ovary syndrome (PCOS) may be at risk for developing PCOS. However, it is not known at which stage of pubertal development the hormonal and metabolic abnormalities ensue in PCOS. Objective: The aim of the study was to assess the reproductive and metabolic profiles of daughters of women with PCOS (PCOSd) during the peripubertal period, a stage during which the gonadal axis is activated and PCOS may become clinically manifest. Design: Ninety-nine PCOSd [30 prepubertal and 69 pubertal (Tanner II-V)] and 84 daughters of control women (Cd) (20 prepubertal and 64 pubertal) were studied. An oral glucose tolerance test, a GnRH agonist test (leuprolide acetate, 10 μg/kg sc), and a transabdominal ultrasound were performed. Gonadotropins, sex steroids, SHBG, glucose, insulin, and lipids were determined. Results: Both groups had similar chronological ages and body mass index SD scores according to Tanner
Publisherdc.publisherEndocrine Society
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceJournal of Clinical Endocrinology and Metabolism
Keywordsdc.subjectEndocrinology, Diabetes and Metabolism
Keywordsdc.subjectClinical Biochemistry
Keywordsdc.subjectBiochemistry (medical)
Títulodc.titleMetabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile