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Regulation of axonal development by the nuclear protein hindsight (pebbled) in the Drosophila visual system

Authordc.contributor.authorOliva, Carlos 
Authordc.contributor.authorSierralta, Jimena 
Cita de ítemdc.identifier.citationDevelopmental Biology, Volumen 344, Issue 2, 2018, Pages 911-921
Abstractdc.description.abstractThe molecules and networks involved in the process of acquisition and maintenance of the form of a mature neuron are not completely known. Using a misexpression screen we identified the gene hindsight as a gene involved in the process of acquisition of the neuronal morphogenesis in the Drosophila adult nervous system. hindsight encodes a transcription factor known for its role in early developmental processes such as embryonic germ band retraction and dorsal closure, as well as in the establishment of cell morphology, planar cell polarity, and epithelial integrity during retinal development. We describe here a novel function for HNT by showing that both loss and gain of function of HNT affects the pathfinding of the photoreceptors axons. By manipulating the timing and level of HNT expression, together with the number of cells manipulated we show here that the function of HNT in axonal guidance is independent of the HNT functions previously reported in retinal cells. Based on genetic in
Publisherdc.publisherAcademic Press Inc.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceDevelopmental Biology
Keywordsdc.subjectAxon guidance
Keywordsdc.subjectEye development
Keywordsdc.subjectNeuronal morphogenesis
Títulodc.titleRegulation of axonal development by the nuclear protein hindsight (pebbled) in the Drosophila visual system
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile