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Heart energy metabolism and its role in the treatment of heart failure Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca

Authordc.contributor.authorCastro, Pablo 
Authordc.contributor.authorGabrielli, Luigi 
Authordc.contributor.authorVerdejo, Hugo 
Authordc.contributor.authorGreig, Douglas 
Authordc.contributor.authorMellado, Rosemarie 
Authordc.contributor.authorConcepción, Roberto 
Authordc.contributor.authorSepulveda, Luis 
Authordc.contributor.authorVukasovic, José Luis 
Authordc.contributor.authorGarcía, Lorena 
Authordc.contributor.authorPizarro, Marcela 
Authordc.contributor.authorPivet, Deisy 
Authordc.contributor.authorCarrillo, Constanza 
Authordc.contributor.authorTapia, Fabiola 
Authordc.contributor.authorNavarro, Mario 
Authordc.contributor.authorTroncoso, Rodrigo 
Authordc.contributor.authorBaraon 
Admission datedc.date.accessioned2019-03-11T13:00:42Z
Available datedc.date.available2019-03-11T13:00:42Z
Publication datedc.date.issued2010
Cita de ítemdc.identifier.citationRevista Medica de Chile, Volumen 138, Issue 8, 2018, Pages 1028-1039
Identifierdc.identifier.issn00349887
Identifierdc.identifier.issn07176163
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165117
Abstractdc.description.abstractIt is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceRevista Medica de Chile
Keywordsdc.subjectDrug therapy
Keywordsdc.subjectHeart failure
Keywordsdc.subjectMetabolism
Títulodc.titleHeart energy metabolism and its role in the treatment of heart failure Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile