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Model of chromosome associations in mus domesticus spermatocytes

Authordc.contributor.authorBerríos, Soledad 
Authordc.contributor.authorManterola, Marcia 
Authordc.contributor.authorPrieto, Zulita 
Authordc.contributor.authorLópez Fenner, Julio 
Authordc.contributor.authorPage, Jesús 
Authordc.contributor.authorFernández Donoso, Raúl 
Cita de ítemdc.identifier.citationBiological Research, Volumen 43, Issue 3, 2018, Pages 275-286
Abstractdc.description.abstractUnderstanding the spatial organization of the chromosomes in meiotic nuclei is crucial to our knowledge of the genome's functional regulation, stability and evolution. This study examined the nuclear architecture of Mus domesticus 2n=40 pachytene spermatocytes, analyzing the associations among autosomal bivalents via their Centromere Telomere Complexes (CTC). The study developed a nuclear model in which each CTC was represented as a 3D computer object. The probability of a given combination of associations among CTC was estimated by simulating a random distribution of 19 indistinguishable CTC over n indistinguishable "cells" on the nuclear envelope. The estimated association frequencies resulting from this numerical approach were similar to those obtained by quantifying actual associations in pachytene spermatocyte spreads. The nuclear localization and associations of CTC through the meiotic prophase in well-preserved nuclei were also analyzed. We concluded that throughout the meiotic
Publisherdc.publisherSociety of Biology of Chile
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceBiological Research
Keywordsdc.subjectBivalent associations
Keywordsdc.subjectHeterochromatin distribution
Keywordsdc.subjectMouse spermatocytes
Keywordsdc.subjectNuclear model
Títulodc.titleModel of chromosome associations in mus domesticus spermatocytes
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile