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The use of adipose tissue-derived stem cells within a dermal substitute improves skin regeneration by increasing neoangiogenesis and collagen synthesis

Authordc.contributor.authorMeruane, Manuel A. 
Authordc.contributor.authorRojas, Mariana 
Authordc.contributor.authorMarcelain Cubillos, Katherine 
Admission datedc.date.accessioned2019-03-11T13:19:28Z
Available datedc.date.available2019-03-11T13:19:28Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationPlastic and Reconstructive Surgery, Volumen 130, Issue 1, 2018, Pages 53-63
Identifierdc.identifier.issn00321052
Identifierdc.identifier.other10.1097/PRS.0b013e3182547e04
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165621
Abstractdc.description.abstractBACKGROUND: Surgical treatment of injuries with loss of skin tissue has improved significantly with the advent of regenerative medicine and tissue bioengineering, and the use of stem cells and dermal substitutes. The success of tissue regeneration depends on optimal local vascularization and the successful integration of the artificial skin. The present study combines the use of autologous adipose-derived stem cells with a commercially available dermal substitute (Integra) for skin regeneration. METHODS: Adipose-derived stem cells were isolated from the inguinal region of eight Sprague-Dawley adult rats, seeded onto a piece of dermal substitute for 48 hours, and then implanted into the same rat, followed by comparison of the evolution with a contralateral implant without adipose-derived stem cells. After 1, 2, and 3 weeks of regeneration in vivo, implants were removed for histologic evaluation. RESULTS: Adipose-derived stem cells adhere properly to the dermal matrix, and autologous tis
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePlastic and Reconstructive Surgery
Keywordsdc.subjectSurgery
Títulodc.titleThe use of adipose tissue-derived stem cells within a dermal substitute improves skin regeneration by increasing neoangiogenesis and collagen synthesis
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile