Show simple item record

Efecto de metformina sobre la expresión del factor de necrosis tumoral-a, los receptores Toll-like 2/4 y la PCR ultra sensible en sujetos obesos con diabetes tipo 2

Authordc.contributor.authorAndrews, Mónica 
Authordc.contributor.authorSoto, Néstor 
Authordc.contributor.authorArredondo Olguín, Miguel 
Admission datedc.date.accessioned2019-03-15T16:04:28Z
Available datedc.date.available2019-03-15T16:04:28Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationRev Med Chile 2012; 140: 1377-1382
Identifierdc.identifier.issn00349887
Identifierdc.identifier.issn07176163
Identifierdc.identifier.other10.4067/S0034-98872012001100001
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165980
Abstractdc.description.abstractBackground: The pharmacological action of metformin goes beyond mere glycemic control, decreasing markers of inflammation and contributing to the reduction of oxidative stress. Aim: To evaluate biochemical, anthropometric and pro-inflammatory markers in obese type 2 diabetic patients treated or not with metformin. Patients and Methods: Obese patients with type 2 diabetes were invited to participate in the study if they were aged more than 40 years, were not receiving insulin, did not have cardiovascular diseases and were not taking anti-inflammatory drugs. A pharmacological history was taken and patients were stratified in two groups whether they were using metformin or not. A fasting blood sample was obtained to measure blood glucose, insulin, lipid levels, C reactive protein (hsCRP) and to isolate peripheral blood mononuclear cells. RNA was isolated from these cells to measure expression of tumor necrosis factor-α (TNF-α), Interleukin-6 (IL-6), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), Toll-Like Receptor 2/4 (TLR 2/4) and beta-2-microglobulin (B2M). Results: Thirty participants were studied. Of these, 16 subjects aged 54.4 ± 5.5 years were treated with metformin and 14 subjects aged 54.9 ± 6.4 years did not receive the drug. Participants receiving metformin had lower levels of hsCRP and lower mRNA relative abundance of TNF-α and TLR 2/4. There were no differences in glucose levels or lipid profile between both groups. Conclusions: Obese diabetic patients treated with metformin had lower levels of hsCRP expression of TNF-α and TLR 2/4, than their counterparts not receiving the drug.
Lenguagedc.language.isosp
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceRevista Médica de Chile
Keywordsdc.subjectC-reactive protein
Keywordsdc.subjectInflammation
Keywordsdc.subjectMetformin
Keywordsdc.subjectTumor necrosis factor-alpha
Títulodc.titleEfecto de metformina sobre la expresión del factor de necrosis tumoral-a, los receptores Toll-like 2/4 y la PCR ultra sensible en sujetos obesos con diabetes tipo 2
Title in another languagedc.title.alternativeEffect of metformin on the expression of tumor necrosis factor-α, Toll like receptors 2/4 and C reactive protein in obese type-2 diabetic patients
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorlaj
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile