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Metformin for the treatment of hyperandrogenism in adolescents with type 1 diabetes mellitus

Authordc.contributor.authorCodner Dujovne, Ethel 
Authordc.contributor.authorIñíguez Vila, Germán 
Authordc.contributor.authorLópez, Patricia 
Authordc.contributor.authorMujica, Verónica 
Authordc.contributor.authorEyzaguirre, Francisca C. 
Authordc.contributor.authorAsenjo, Sylvia 
Authordc.contributor.authorTorrealba, Isabel 
Authordc.contributor.authorCassorla Goluboff, Fernando 
Admission datedc.date.accessioned2019-03-15T16:05:43Z
Available datedc.date.available2019-03-15T16:05:43Z
Publication datedc.date.issued2013
Cita de ítemdc.identifier.citationHormone Research in Paediatrics, Volumen 80, Issue 5, 2018, Pages 343-349
Identifierdc.identifier.issn16632826
Identifierdc.identifier.issn16632818
Identifierdc.identifier.other10.1159/000355513
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/166046
Abstractdc.description.abstract© 2013 S. Karger AG, Basel.Background: A high prevalence of hyperandrogenism has been reported in women with type 1 diabetes (T1D). Metformin has been used as a therapeutic agent in patients with polycystic ovarian syndrome and in T1D patients without hyperandrogenism. This study sought to determine the effect of metformin on hyperandrogenism and ovarian function in adolescents with T1D. Methods: We recruited 24 girls with T1D. The participants had hyperandrogenism and displayed suboptimal metabolic control. The patients were enrolled in a randomized, double-blind, placebo-controlled trial. One group received metformin (850 mg bid) and the other group received a placebo. Treatment was administered for 9 months. Ovulation, steroids and gonadotropin levels were evaluated. Results: Metformin treatment was associated with decreases in testosterone, free androgen index, androstenedione, 17-OH progesterone and estradiol levels. The girls who were treated with placebo showed stable steroid, g
Lenguagedc.language.isoen
Publisherdc.publisherS. Karger AG
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceHormone Research in Paediatrics
Keywordsdc.subjectAdolescence
Keywordsdc.subjectHyperandrogenism
Keywordsdc.subjectMetformin
Keywordsdc.subjectType 1 diabetes
Títulodc.titleMetformin for the treatment of hyperandrogenism in adolescents with type 1 diabetes mellitus
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile