The Neuroplastin adhesion molecules: Key regulators of neuronal plasticity and synaptic function
Author
dc.contributor.author
Beesley, Philip W.
Author
dc.contributor.author
Herrera Molina, Rodrigo
Author
dc.contributor.author
Smalla, Karl-Heinz
Author
dc.contributor.author
Seidenbecher, Constanze
Admission date
dc.date.accessioned
2019-03-15T16:08:52Z
Available date
dc.date.available
2019-03-15T16:08:52Z
Publication date
dc.date.issued
2014
Cita de ítem
dc.identifier.citation
J. Neurochem. (2014) 131, 268–283
Identifier
dc.identifier.issn
14714159
Identifier
dc.identifier.issn
00223042
Identifier
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10.1111/jnc.12816
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/166352
Abstract
dc.description.abstract
The Neuroplastins Np65 and Np55 are neuronal and synapseenriched immunoglobulin superfamily molecules that play
important roles in a number of key neuronal and synaptic
functions including, for Np65, cell adhesion. In this review we
focus on the physiological roles of the Neuroplastins in
promoting neurite outgrowth, regulating the structure and
function of both inhibitory and excitatory synapses in brain,
and in neuronal and synaptic plasticity. We discuss the
underlying molecular and cellular mechanisms by which the
Neuroplastins exert their physiological effects and how these
are dependent upon the structural features of Np65 and Np55,
which enable them to bind to a diverse range of protein
partners. In turn this enables the Neuroplastins to interact with
a number of key neuronal signalling cascades. These include:
binding to and activation of the fibroblast growth factor
receptor; Np65 trans-homophilic binding leading to activation
of p38 MAPK and internalization of glutamate (GluR1) receptor subunits; acting as accessory proteins for monocarboxylate
transporters, thus affecting neuronal energy supply, and
binding to GABAA a1, 2 and 5 subunits, thus regulating the
composition and localization of GABAA receptors. An emerging theme is the role of the Neuroplastins in regulating the
trafficking and subcellular localization of specific binding
partners. We also discuss the involvement of Neuroplastins
in a number of pathophysiological conditions, including
ischaemia, schizophrenia and breast cancer and the role of
a single nucleotide polymorphism in the human Neuroplastin
(NPTN) gene locus in impairment of cortical development and
cognitive functions.