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Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion

Authordc.contributor.authorMizgier, María Luisa 
Authordc.contributor.authorCataldo, Luis R. 
Authordc.contributor.authorGutierrez, Juan 
Authordc.contributor.authorSantos, José Luis 
Authordc.contributor.authorCasas, Mariana 
Authordc.contributor.authorLlanos Vidal, Paola 
Authordc.contributor.authorContreras Ferrat, Ariel Eduardo 
Authordc.contributor.authorMoro, Cedric 
Authordc.contributor.authorBouzakri, Karim 
Authordc.contributor.authorGalgani Fuentes, José 
Cita de ítemdc.identifier.citationJournal of Diabetes Research, Volumen 2017,
Abstractdc.description.abstract© 2017 Maria L. Mizgier et al. Fasting to postprandial transition requires a tight adjustment of insulin secretion to its demand, so tissue (e.g., skeletal muscle) glucose supply is assured while hypo-/hyperglycemia are prevented. High muscle glucose disposal after meals is pivotal for adapting to increased glycemia and might drive insulin secretion through muscle-released factors (e.g., myokines). We hypothesized that insulin influences myokine secretion and then increases glucose-stimulated insulin secretion (GSIS). In conditioned media from human myotubes incubated with/without insulin (100 nmol/L) for 24 h, myokines were qualitatively and quantitatively characterized using an antibody-based array and ELISA-based technology, respectively. C57BL6/J mice islets and Wistar rat beta cells were incubated for 24 h with control and conditioned media from noninsulin- and insulin-treated myotubes prior to GSIS determination. Conditioned media from insulin-treated versus nontreated myotubes h
Publisherdc.publisherHindawi Publishing Corporation
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceJournal of Diabetes Research
Keywordsdc.subjectEndocrinology, Diabetes and Metabolism
Títulodc.titleEffect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile