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Endogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative stress in Trypanosoma cruzi

Authordc.contributor.authorRojas, Diego A. 
Authordc.contributor.authorUrbina, Fabiola 
Authordc.contributor.authorMoreira Ramos, Sandra 
Authordc.contributor.authorCastillo, Christian 
Authordc.contributor.authorKemmerling Weis, Ulrike 
Authordc.contributor.authorLapier, Michel 
Authordc.contributor.authorMaya Arango, Juan 
Authordc.contributor.authorSolari Illescas, Aldo 
Authordc.contributor.authorMaldonado, Edio 
Admission datedc.date.accessioned2019-03-18T12:01:26Z
Available datedc.date.available2019-03-18T12:01:26Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationPLoS Neglected Tropical Diseases, Volumen 12, Issue 2, 2018,
Identifierdc.identifier.issn19352735
Identifierdc.identifier.issn19352727
Identifierdc.identifier.other10.1371/journal.pntd.0006220
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/167400
Abstractdc.description.abstract© 2018 Rojas et al. Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria (kinetoplast), where specific protein complexes detect and eliminate damage to DNA. One group of these proteins is the DNA polymerases. In particular, Tc DNA polymerase β participates in kinetoplast DNA replication and repair. However, the mechanisms which control its expression under oxidative stress are still unknown. Here we describe the effect of oxidative stress on the expression and function of Tc DNA polymerase β To this end parasite cells (epimastigotes and trypomastigotes) were exposed to peroxide during short periods of time. Tc DNA polymerase β which was associated physically with kinetoplast DNA, showed increased protein levels in response to peroxide damage in both parasite forms analyzed. Two forms of DNA polymerase β were identified and ove
Lenguagedc.language.isoen
Publisherdc.publisherPublic Library of Science
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePLoS Neglected Tropical Diseases
Keywordsdc.subjectPublic Health, Environmental and Occupational Health
Keywordsdc.subjectInfectious Diseases
Títulodc.titleEndogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative stress in Trypanosoma cruzi
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile