Electroactive 3D printed scaffolds based on percolated composites of polycaprolactone with thermally reduced graphene oxide for antibacterial and tissue engineering applications
Author
dc.contributor.author
Angulo Pineda, Carolina
Author
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Srirussamee, Kasama
Author
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Palma Fluxá, Patricia
Author
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Fuenzalida Escobar, Víctor
Author
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Cartmell, Sarah
Author
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Palza Cordero, Humberto
Admission date
dc.date.accessioned
2020-05-20T22:16:39Z
Available date
dc.date.available
2020-05-20T22:16:39Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Nanomaterials 2020, 10, 428
es_ES
Identifier
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10.3390/nano10030428
Identifier
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https://repositorio.uchile.cl/handle/2250/174889
Abstract
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Applying electrical stimulation (ES) could affect different cellular mechanisms, thereby producing a bactericidal effect and an increase in human cell viability. Despite its relevance, this bioelectric effect has been barely reported in percolated conductive biopolymers. In this context, electroactive polycaprolactone (PCL) scaffolds with conductive Thermally Reduced Graphene Oxide (TrGO) nanoparticles were obtained by a 3D printing method. Under direct current (DC) along the percolated scaffolds, a strong antibacterial effect was observed, which completely eradicated S. aureus on the surface of scaffolds. Notably, the same ES regime also produced a four-fold increase in the viability of human mesenchymal stem cells attached to the 3D conductive PCL/TrGO scaffold compared with the pure PCL scaffold. These results have widened the design of novel electroactive composite polymers that could both eliminate the bacteria adhered to the scaffold and increase human cell viability, which have great potential in tissue engineering applications.
es_ES
Patrocinador
dc.description.sponsorship
CONICYT-PCHA/Doctorado
21150921
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT
1150130
Project Millennium Nuclei in Soft Smart Mechanical Metamaterials, Santiago, Chile
Electroactive 3D printed scaffolds based on percolated composites of polycaprolactone with thermally reduced graphene oxide for antibacterial and tissue engineering applications